支架——再生的基础：一篇叙述性综述
Scaffolds--The Ground for Regeneration: A Narrative Review.
作者信息
Joshi Sourabh Ramesh, Pendyala Gowri Swaminatham, Shah Pratima, Mopagar Viddyasagar Prabhakar, Padmawar Neeta, Padubidri Meghana
机构信息
Department of Pediatric & Preventive Dentistry, Rural Dental College, Loni, Maharashtra, India.
Department of Peridontics, Rural Dental College, Loni, Maharashtra, India.
出版信息
J Int Soc Prev Community Dent. 2020 Nov 24;10(6):692-699. doi: 10.4103/jispcd.JISPCD_198_20. eCollection 2020 Nov-Dec.
AIM
The aim of this study was to comprehensively review the various biomaterials used as scaffolds, rates of biodegradability of natural, artificial and composite hybrid scaffolds, and the role of controlled biodegradability in tissue engineering.
MATERIALS AND METHODS
An electronic search for systematic review was conducted in PubMed/MEDLINE (www.ncbi.nlm.nih.gov), Cochrane (www.cochrane.org), Scopus (www.scopus.com) databases, and dental journals related to endodontics and pediatric dentistry to identify the research investigations associated with the degradation profiles, factors relating to degradation, rates of biodegradability and the role of controlled biodegradability of natural, artificial and composite scaffolds. A sample of 17 relevant studies and case reports were identified in our search of 100 using simple random sampling.
RESULTS
Naturally derived scaffolds degrade at a much higher rate than artificial and composite scaffolds. The degradation profiles of composite scaffolds can be much better controlled than naturally derived scaffolds.
CONCLUSION
Composite scaffolds are more favorable as compared to natural or artificial scaffolds, as it has superior mechanical properties, minimal immune response, and a controlled rate of degradation and consequent tissue regeneration.
目的
本研究旨在全面综述用作支架的各种生物材料、天然、人工和复合杂交支架的生物降解率，以及可控生物降解性在组织工程中的作用。
材料与方法
结果
天然衍生的支架比人工和复合支架降解速度快得多。复合支架的降解概况比天然衍生的支架更易于控制。
结论
与天然或人工支架相比，复合支架更具优势，因为它具有卓越的机械性能、最小的免疫反应以及可控的降解速率和随之而来的组织再生能力。
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