Gathani Kinjal M, Raghavendra Srinidhi Surya
Department of Conservative Dentistry and Endodontics, Sinhgad Dental College and Hospital, Pune, Maharashtra, India.
Dent Res J (Isfahan). 2016 Sep;13(5):379-386. doi: 10.4103/1735-3327.192266.
Root canal therapy has enabled us to save numerous teeth over the years. The most desired outcome of endodontic treatment would be when diseased or nonvital pulp is replaced with healthy pulp tissue that would revitalize the teeth through regenerative endodontics. 'A search was conducted using the Pubmed and MEDLINE databases for articles with the criteria 'Platelet rich plasma', 'Platelet rich fibrin', 'Stem cells', 'Natural and artificial scaffolds' from 1982-2015'. Tissues are organized as three-dimensional structures, and appropriate scaffolding is necessary to provide a spatially correct position of cell location and regulate differentiation, proliferation, or metabolism of the stem cells. Extracellular matrix molecules control the differentiation of stem cells, and an appropriate scaffold might selectively bind and localize cells, contain growth factors, and undergo biodegradation over time. Different scaffolds facilitate the regeneration of different tissues. To ensure a successful regenerative procedure, it is essential to have a thorough and precise knowledge about the suitable scaffold for the required tissue. This article gives a review on the different scaffolds providing an insight into the new developmental approaches on the horizon.
多年来，根管治疗使我们能够挽救无数牙齿。牙髓病治疗最理想的结果是，用健康的牙髓组织替代患病或无活力的牙髓，通过再生牙髓治疗使牙齿恢复活力。我们使用PubMed和MEDLINE数据库，检索了1982年至2015年间符合“富血小板血浆”、“富血小板纤维蛋白”、“干细胞”、“天然和人工支架”标准的文章。组织是三维结构，需要合适的支架来提供细胞定位的空间正确位置，并调节干细胞的分化、增殖或代谢。细胞外基质分子控制干细胞的分化，合适的支架可能会选择性地结合并定位细胞，包含生长因子，并随时间发生生物降解。不同的支架促进不同组织的再生。为确保再生过程成功，必须对所需组织的合适支架有全面而精确的了解。本文综述了不同的支架，深入探讨了即将出现的新发展方法。
