Thakkar Bhaumik, Chandran Sarath, Vishnoi Shivlal, Nadig Priyadarshini, Raval Ruchi, Doshi Priyanka
Department of Periodontics and Implantology, Manubhai Patel Dental College & Hospital, Vadodara, Gujarat, India.
J Int Soc Prev Community Dent. 2020 Nov 24;10(6):743-751. doi: 10.4103/jispcd.JISPCD_200_19. eCollection 2020 Nov-Dec.
To compare the regenerative potential of platelet-rich fibrin alone and in combination with bovine bone graft in intraosseous defect by the single flap approach.
A total of 32 sites of intrabony defects were selected and were treated with platelet-rich fibrin (PRF) alone or in combination with bovine bone graft. Clinical parameters [Gingival index (GI), probing depth (PD), clinical attachment level (CAL), Gingival recession, and radiographic parameters (defect fill, alveolar crest level, and defect depth)] were recorded at baseline, 3 months, and 6 months.
Statistical analysis was done by independent and paired -test. There were statistically significant changes in GI, PD reduction, CAL gain, defect fill, alveolar crest level changes, and defect depth resolution from baseline, 3 months, and 6 months in both the groups ( < 0.001). On intergroup comparison, Group II showed statistically significant changes in a reduction in pocket depth and defect depth resolution at < 0.001.
PRF in combination with bovine bone graft was more effective in the treatment of intrabony defects.
通过单瓣入路比较富血小板纤维蛋白单独使用及与牛骨移植联合使用对骨内缺损的再生潜力。
共选择32处骨内缺损部位，分别单独使用富血小板纤维蛋白（PRF）或与牛骨移植联合使用进行治疗。在基线、3个月和6个月时记录临床参数[牙龈指数（GI）、探诊深度（PD）、临床附着水平（CAL）、牙龈退缩]以及影像学参数（缺损填充、牙槽嵴水平和缺损深度）。
采用独立样本t检验和配对t检验进行统计学分析。两组在基线、3个月和6个月时，GI、PD降低、CAL增加、缺损填充、牙槽嵴水平变化和缺损深度消退方面均有统计学显著变化（P<0.001）。组间比较显示，第二组在袋深度降低和缺损深度消退方面有统计学显著变化（P<0.001）。
PRF与牛骨移植联合使用在治疗骨内缺损方面更有效。
