Department of Physical Sciences, Indian Institute of Science Education & Research (IISER) Mohali, Punjab, India.
MDI Biological Laboratory, Bar Harbor, ME, USA.
Nat Prod Res. 2022 Jan;36(1):390-395. doi: 10.1080/14786419.2020.1762190. Epub 2020 May 7.
is a medicinal plant which is widely used in different traditional medicinal systems to treat several diseases. We have identified the differential distribution of phytomedicinally important metabolites in the pericarp, skin and seeds of fruit via NMR spectroscopy. Multivariate statistical analysis showed a clustering of the metabolic profiles of seeds and pericarp, and their clear separation from the metabolic profile of the skin. The total phenolic and flavonoid content of the fruit extracts were estimated via bioassays, the radical scavenging activity was estimated via DPPH and ABTS assays and an inhibitory activity test of -glucosidase was also performed. The pericarp and seeds contained significant amounts of phenolic compounds and flavonoids, indicating that they are a good source for antioxidants. The skin contained a significantly higher amount of phytosterols such as Charantin and momordicine, which are known to correlate with antidiabetic activity.
是一种药用植物，在不同的传统医学体系中被广泛用于治疗多种疾病。我们通过 NMR 光谱法鉴定了果皮、种皮和种子中具有药用价值的代谢物的差异分布。多元统计分析显示，种子和果皮的代谢谱聚类，与皮肤的代谢谱明显分离。通过生物测定法估计了果实提取物的总酚和类黄酮含量，通过 DPPH 和 ABTS 测定法估计了自由基清除活性，并进行了 -葡萄糖苷酶抑制活性测试。果皮和种子含有大量的酚类化合物和类黄酮，表明它们是抗氧化剂的良好来源。皮肤含有大量的植物甾醇，如苦瓜素和苦瓜苷，已知它们与抗糖尿病活性相关。
