具有抗癌潜力的唑-磺胺类杂合体的最新进展。
Recent development of azole-sulfonamide hybrids with the anticancer potential.
机构信息
Huludao Central Hospital, Huludao, 125000, Liaoning, China.
出版信息
Future Med Chem. 2024;16(12):1267-1281. doi: 10.1080/17568919.2024.2351291. Epub 2024 May 30.
Abstract
Cancer exhibits heterogeneity that enables adaptability and remains grand challenges for effective treatment. Chemotherapy is a validated and critically important strategy for the treatment of cancer, but the emergence of multidrug resistance which may lead to recurrence of disease or even death is a major hurdle for successful chemotherapy. Azoles and sulfonamides are important anticancer pharmacophores, and azole-sulfonamide hybrids have the potential to simultaneously act on dual/multiple targets in cancer cells, holding great promise to overcome drug resistance. This review outlines the current scenario of azole-sulfonamide hybrids with the anticancer potential, and the structure-activity relationships as well as mechanisms of action are also discussed, covering articles published from 2020 onward.
摘要
癌症表现出的异质性使其具有适应性，仍然是有效治疗的重大挑战。化疗是一种经过验证的、至关重要的癌症治疗策略，但多药耐药的出现可能导致疾病复发甚至死亡，这是化疗成功的主要障碍。唑类和磺胺类是重要的抗癌药效团，唑-磺胺类杂合体有可能同时作用于癌细胞中的双重/多个靶点，有望克服耐药性。本综述概述了具有抗癌潜力的唑-磺胺类杂合体的现状，讨论了构效关系和作用机制，涵盖了 2020 年以来发表的文章。
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