Qiao Rui, Ye Leping, Hu Kun, Yu Shuling, Yang Weiguang, Liu Miaochang, Chen Jiuxi, Ding Jinchang, Wu Huayue
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China.
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, P. R. China.
Org Biomol Chem. 2017 Mar 8;15(10):2168-2173. doi: 10.1039/c6ob02352e.
The first example of a copper-catalyzed halogen-free protocol to construct indazolo[3,2-b]quinazolinones was developed through sequential inert C-O bond cleavage followed by intramolecular C-N bond formation. This protocol represents an efficient synthetic tool for accessing a more diverse range of functionalized indazolo[3,2-b]quinazolinones. The structure of the newly synthesized indazolo[3,2-b]quinazolinones was unambiguously confirmed by X-ray crystal diffraction analysis.
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