Sanders P W, Herrera G A, Ball G V
Department of Medicine, University of Alabama, Birmingham.
Nephron. 1988;48(2):121-5. doi: 10.1159/000184889.
Scleroderma renal crisis (SRC) is defined as sudden development of accelerated hypertension, hyperreninemia, and acute renal failure in a patient with progressive systemic sclerosis (PSS). Although the diagnosis of PSS is generally straightforward because of dermal fibrosis, we report 2 patients who had PSS with SRC without the characteristic fibrotic skin changes of scleroderma. PSS should be considered in the differential diagnosis of unexplained acute renal failure and accelerated hypertension even though the cutaneous fibrotic manifestations of the disease may be absent.
硬皮病肾危象（SRC）的定义为，在进行性系统性硬化症（PSS）患者中突然出现的急进性高血压、高肾素血症和急性肾衰竭。尽管由于皮肤纤维化，PSS的诊断通常较为直接，但我们报告了2例患有PSS合并SRC的患者，他们并无硬皮病典型的纤维化皮肤改变。即使疾病的皮肤纤维化表现可能不存在，在不明原因的急性肾衰竭和急进性高血压的鉴别诊断中也应考虑PSS。
