Xia Wei, Qin Tao, Suska Felicia, Engqvist Håkan
Applied Materials Science, Department of Engineering Sciences, Uppsala University, Lägerddsv 1, 75120 Uppsala, Sweden.
Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Arvid Wallgrens Backe 20, 40530 Göteborg, Sweden.
ACS Biomater Sci Eng. 2016 May 9;2(5):734-740. doi: 10.1021/acsbiomaterials.5b00499. Epub 2016 Apr 18.
Sealing exposed dental tubules is the most effective and long-term way to relieve the pain induced by dental sensitivity. A bioactive hollow sphere (strontium substituted calcium phosphate) was synthesized and added in toothpaste to study its effect on dental hypersensitivity via tooth tubules occlusion and mineralization. The size of spheres is perfect for penetrating into dental tubules, reaching to 20 μm into the tubules. The exposed dental tubules were occluded by spheres and new apatite layer after 3 days brushing. The spheres attached to the surface of dentin and the mineralized surface contained two layers, a porous layer followed by a dense apatite layer. The porous layer can be dissolved in an acidic solution, but the following dense layer could be kept even after soaking in an acid solution. In conclusion, Sr-substituted calcium phosphate spheres could be a good candidate for at-home treatment of dental hypersensitivity.
封闭暴露的牙本质小管是缓解牙齿敏感引起疼痛的最有效且长期的方法。合成了一种生物活性空心球（锶取代磷酸钙）并添加到牙膏中，通过牙本质小管堵塞和矿化来研究其对牙齿过敏的影响。球体尺寸非常适合穿透牙本质小管，可深入小管达20μm。经过3天刷牙后，暴露的牙本质小管被球体和新的磷灰石层堵塞。球体附着在牙本质表面，矿化表面包含两层，先是多孔层，接着是致密的磷灰石层。多孔层可在酸性溶液中溶解，但即使浸泡在酸性溶液中，随后的致密层仍能保留。总之，锶取代磷酸钙球体可能是家庭治疗牙齿过敏的良好候选材料。
