Huang Suping, Li Chunxia, Xiao Qi
State Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, Hunan, China.
School of Resources Processing and Bioengineering, Central South University, Changsha, 410083, Hunan, China.
Nanoscale Res Lett. 2017 Dec;12(1):275. doi: 10.1186/s11671-017-2051-7. Epub 2017 Apr 13.
In this paper, yolk-shell hollow nanospheres of amorphous calcium phosphate (ACP) are prepared, and its loading capacity is investigated by comparing with that of solid-shell hollow structure ACP and cage-shell hollow structure ACP. Results show that the products are yolk @ cage-shell of ACP with large shell's pores size (15-40 nm) and large cavity volume. Adsorption results show that the loading capacity of yolk @ cage-shell hollow spherical ACP is very high, which is more than twice that of hollow ACP and 1.5 times of cage-like ACP. The main reasons are that the big shell's pore size contributes the large molecular doxorubicin hydrochloride (DOX · HCl) to enter the inner of hollow spheres easier, and the yolk-shell structure provides larger interior space and more adsorption sites for loading drugs.
本文制备了非晶态磷酸钙（ACP）的蛋黄壳空心纳米球，并通过与实心壳空心结构ACP和笼状壳空心结构ACP进行比较，研究了其负载能力。结果表明，产物为具有大壳孔径（15 - 40nm）和大腔体体积的ACP蛋黄@笼状壳结构。吸附结果表明，蛋黄@笼状壳空心球形ACP的负载能力非常高，是空心ACP的两倍多，是笼状ACP的1.5倍。主要原因是大的壳孔径有助于大分子盐酸阿霉素（DOX·HCl）更容易进入空心球内部，并且蛋黄壳结构为药物负载提供了更大的内部空间和更多的吸附位点。
