Adult Oral Health, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK.
Dent Mater. 2012 Feb;28(2):168-78. doi: 10.1016/j.dental.2011.11.021. Epub 2011 Dec 23.
Dentin hypersensitivity (DH) is a commonly occurring dental condition, and bioactive glasses (BG) are used in dentifrice formulations for treating DH by forming a surface layer of hydroxycarbonate apatite (HCA) on the tooth, thereby occluding exposed dentinal tubules. Fluoride-containing BG, however, form fluorapatite, which is more stable toward acid attack, and provide a more sustainable option for treating DH.
Melt-derived multi-component BG (SiO(2)-P(2)O(5)-CaO-CaF(2)-SrO-SrF(2)-ZnO-Na(2)O-K(2)O) with increasing CaF(2)+SrF(2) content (0-32.7 mol%) were prepared. Apatite formation, occlusion of dentinal tubules in dentin discs and ion release in Tris buffer were characterized in vitro over up to 7 days using X-ray diffraction, infrared spectroscopy, scanning electron microscopy and inductively coupled plasma emission spectroscopy.
The fluoride-containing bioactive glasses formed apatite from as early as 6h, while the fluoride-free control did not form apatite within 7 days. The glasses successfully occluded dentinal tubules by formation of apatite crystals and released ions such as fluoride, strontium and potassium.
Fluoride significantly improved apatite formation of the BG, allowing for treatment of DH by occlusion of dentinal tubules. The BG also released therapeutically active ions, such as strontium and fluoride for caries prevention, zinc for bactericidal properties and potassium, which is used as a desensitizing agent in dentifrices.
牙本质敏感（DH）是一种常见的牙科病症，生物活性玻璃（BG）被用于牙膏配方中，通过在牙齿表面形成羟基磷灰石（HCA）层来治疗 DH，从而封闭暴露的牙本质小管。然而，含氟 BG 会形成氟磷灰石，其对酸的攻击更稳定，并为治疗 DH 提供了更可持续的选择。
制备了多组分熔融衍生 BG（SiO(2)-P(2)O(5)-CaO-CaF(2)-SrO-SrF(2)-ZnO-Na(2)O-K(2)O），其 CaF(2)+SrF(2) 含量（0-32.7 mol%）逐渐增加。采用 X 射线衍射、红外光谱、扫描电子显微镜和电感耦合等离子体发射光谱法，在 Tris 缓冲液中对牙本质片上的牙本质小管封闭和离子释放进行了长达 7 天的体外特征研究。
含氟生物活性玻璃早在 6 小时内就形成了磷灰石，而无氟对照在 7 天内没有形成磷灰石。玻璃通过形成磷灰石晶体成功地封闭了牙本质小管，并释放了氟、锶和钾等离子。
氟显著改善了 BG 的磷灰石形成，允许通过封闭牙本质小管来治疗 DH。BG 还释放了治疗活性离子，如用于预防龋齿的锶和氟、用于杀菌的锌以及用于牙膏脱敏的钾。
