Singh Anupam K, Jena Anuraag, Kumar-M Praveen, Jha Daya Krishna, Sharma Vishal
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Intest Res. 2022 Jan;20(1):134-143. doi: 10.5217/ir.2020.00108. Epub 2021 Jan 18.
BACKGROUND/AIMS: Coronavirus disease 2019 (COVID-19) is recognized to have variable clinical manifestations. The clinical presentation of patients with inflammatory bowel disease (IBD) having COVID-19 is unclear.
We identified articles reporting about the clinical presentation of COVID-19 in those with underlying IBD from PubMed and Embase. The studies, irrespective of design or language, were included. The overall pooled frequency of various symptoms was estimated. Joanna Briggs Institute Critical appraisal checklist was used to assess the quality of studies.
Eleven studies, including 1,325 patients, were included in the pooled analysis. The pooled estimates for clinical presentation were; fever: 67.53% (95% confidence interval [CI], 45.38-83.88), cough: 59.58% (95% CI, 45.01-72.63), diarrhea: 27.26% (95% CI, 19.51-36.69), running nose: 27% (95% CI, 15.26-43.19) and dyspnea: 25.29% (95% CI, 18.52-33.52). The pooled prevalence rates for abdominal pain, nausea and vomiting were 13.08% (95% CI, 9.24-18.19), 10.08% (95% CI, 5.84-16.85) and 8.80% (95% CI, 4.43-16.70) per 100 population, respectively.
The clinical presentation of COVID-19 in IBD patients is similar to the general population.
背景/目的：2019冠状病毒病（COVID-19）具有多种临床表现。炎症性肠病（IBD）患者感染COVID-19后的临床表现尚不清楚。
我们从PubMed和Embase中检索了关于IBD患者感染COVID-19临床表现的文章。纳入的研究不考虑设计或语言。估计了各种症状的总体合并频率。使用乔安娜·布里格斯研究所的批判性评价清单来评估研究质量。
11项研究共纳入1325例患者进行合并分析。临床表现的合并估计值为：发热：67.53%（95%置信区间[CI]，45.38-83.88），咳嗽：59.58%（95%CI，45.01-72.63），腹泻：27.26%（95%CI，19.51-36.69），流涕：27%（95%CI，15.26-43.19），呼吸困难：25.29%（95%CI，18.52-33.52）。每100人中腹痛、恶心和呕吐的合并患病率分别为13.08%（95%CI，9.24-18.19）、10.08%（95%CI，5.84-16.85）和8.80%（95%CI，4.43-16.70）。
IBD患者感染COVID-19后的临床表现与普通人群相似。
