Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
PLoS One. 2024 Oct 30;19(10):e0312545. doi: 10.1371/journal.pone.0312545. eCollection 2024.
This study focused on the gastrointestinal (GI) symptoms in the omicron variant infection and the related factors based on digestive health.
A cross-sectional study was conducted on individuals infected with the omicron variant. A structured questionnaire was developed to gather their demographic characteristics, preexisting digestive problems (diseases & symptoms), and clinical manifestations during the infection.
11,484 questionnaires were received from online platforms. 7,929 infected participants were selected based on inclusion and exclusion criteria. Among them, 4,225 (53.3%) were females, and the mean age was 36.0±8.8 years old. In general, the proportion of GI symptoms in the omicron variant infection was 31.4% (62.6% and 25.0% in participants with pre-existing digestive problems and those without, respectively). The participants with pre-existing digestive problems exhibited more severe clinical manifestations during infection compared to those without. Notably, participants with gastrointestinal symptoms during the infection had more severe clinical manifestations, regardless of basic digestive health. Upper, rather than lower GI symptoms were more closely associated with the severity of the clinical manifestations. NSAIDs may increase the occurrence of GI symptoms in participants with a healthy digestive system but not in those with preexisting digestive problems.
Patients infected with the omicron variant may experience more severe clinical symptoms if they have gastrointestinal issues. Digestive health strongly influences the occurrence of gastrointestinal symptoms and the severity of clinical manifestations.
本研究聚焦于基于消化健康的奥密克戎变异感染中的胃肠道（GI）症状及其相关因素。
对感染奥密克戎变异的个体进行横断面研究。制定了一份结构化问卷，以收集他们的人口统计学特征、预先存在的消化问题（疾病和症状）以及感染期间的临床表现。
从在线平台收到了 11484 份问卷。根据纳入和排除标准，选择了 7929 名感染参与者。其中，4225 名（53.3%）为女性，平均年龄为 36.0±8.8 岁。总体而言，奥密克戎变异感染中 GI 症状的比例为 31.4%（有预先存在的消化问题和没有消化问题的参与者分别为 62.6%和 25.0%）。与没有预先存在的消化问题的参与者相比，有预先存在的消化问题的参与者在感染期间表现出更严重的临床表现。值得注意的是，感染期间出现胃肠道症状的参与者无论基本消化健康状况如何，其临床表现都更为严重。上消化道症状而非下消化道症状与临床表现的严重程度更为密切相关。非甾体抗炎药（NSAIDs）可能会增加消化健康的参与者出现胃肠道症状的几率，但不会增加有预先存在的消化问题的参与者出现胃肠道症状的几率。
感染奥密克戎变异的患者如果出现胃肠道问题，可能会经历更严重的临床症状。消化健康状况强烈影响胃肠道症状的发生和临床表现的严重程度。
