Zhang JieLing, Li Kai, Zheng HuiFen, Zhu YiPing
Wannan Medical College, Wuhu, Anhui, China.
Department of Oncology, Yijishan Hospital, Wuhu, Anhui, China.
Neoplasma. 2021 Mar;68(2):240-252. doi: 10.4149/neo_2020_201012N1073. Epub 2021 Jan 14.
Colorectal cancer (CRC) is one of the most common malignancies globally, and the morbidity and mortality rates associated with it are among the highest around the world. Not even great advances in colorectal cancer diagnosis and treatment technologies have been able to increase the 5-year survival rate in this disease. Recidivation and metastasis are the main causes of death in CRC, although the underlying mechanism remains unknown. Long non-coding RNA (lncRNA) is a type of non-coding RNA that is greater than 200 nt in length. LncRNAs are involved in cell proliferation, apoptosis, metastasis, and differentiation. Abnormal expression of lncRNAs is reported in various diseases. Relevant studies have demonstrated that lncRNAs are capable of interacting with DNAs, RNAs, and proteins, thereby regulating the Wnt, p53, and other signaling pathways and playing an important role in the biogenesis, progression, metastasis, and drug resistance in CRC. In the present report, recent progress in the research related to lncRNAs in colorectal cancer is reviewed.
结直肠癌（CRC）是全球最常见的恶性肿瘤之一，与之相关的发病率和死亡率位居世界前列。即便结直肠癌诊断和治疗技术取得了巨大进步，也未能提高该疾病的5年生存率。复发和转移是结直肠癌死亡的主要原因，但其潜在机制尚不清楚。长链非编码RNA（lncRNA）是一类长度大于200 nt的非编码RNA。lncRNAs参与细胞增殖、凋亡、转移和分化。lncRNAs在多种疾病中存在异常表达。相关研究表明，lncRNAs能够与DNA、RNA和蛋白质相互作用，从而调节Wnt、p53等信号通路，并在结直肠癌的发生、发展、转移和耐药性中发挥重要作用。在本报告中，对结直肠癌中lncRNAs相关研究的最新进展进行了综述。
