Luo Jian, Qu Jian, Wu Dong-Kai, Lu Zhi-Li, Sun Yue-Sheng, Qu Qiang
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, P. R. China.
Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, P. R. China.
Oncotarget. 2017 Mar 28;8(13):22187-22202. doi: 10.18632/oncotarget.14728.
Colorectal cancer (CRC) is a common gastrointestinal cancer, with a high incidence and high mortality. Long non-coding RNAs (lncRNAs) are involved in the development, invasion and metastasis, early diagnosis, prognosis, the chemoresistance and radioresistance of CRC through interference with mRNA activity, directly combining with proteins to regulate their activity or alter their localization, influencing downstream gene expression by inhibiting RNA polymerase and regulating gene expression as competing endogenous RNAs. Recent progress in next generation sequencing and transcriptome analysis has revealed that tissue and cancer-type specific lncRNAs could be useful prognostic markers. Here, the CRC-associated lncRNAs from recent studies until October 2016 are reviewed and multiple studies that have confirmed CRC-associated lncRNAs are summarized. This review may be helpful in understanding the overall relationships between the lncRNAs involved in CRC.
结直肠癌（CRC）是一种常见的胃肠道癌症，具有高发病率和高死亡率。长链非编码RNA（lncRNAs）通过干扰mRNA活性、直接与蛋白质结合以调节其活性或改变其定位、抑制RNA聚合酶影响下游基因表达以及作为竞争性内源性RNA调节基因表达，参与了结直肠癌的发生发展、侵袭转移、早期诊断、预后以及化疗耐药和放疗抵抗。新一代测序和转录组分析的最新进展表明，组织和癌症类型特异性lncRNAs可能是有用的预后标志物。在此，对截至2016年10月的近期研究中与结直肠癌相关的lncRNAs进行综述，并总结了多项证实与结直肠癌相关的lncRNAs的研究。这篇综述可能有助于理解参与结直肠癌的lncRNAs之间的整体关系。
