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法国的高血压治疗及降压治疗依从性:社会经济因素和基层医疗在ESTEBAN调查中的作用

Treatment and adherence to antihypertensive therapy in France: the roles of socioeconomic factors and primary care medicine in the ESTEBAN survey.

作者信息

Vallée Alexandre, Grave Clémence, Gabet Amélie, Blacher Jacques, Olié Valérie

机构信息

Diagnosis and Therapeutic Center, Hypertension and Cardiovascular Prevention Unit, Hôtel-Dieu Hospital, Paris-Descartes University, AP-HP, Paris, France.

Santé Publique France, The French Public Health Agency, Saint-Maurice, France.

出版信息

Hypertens Res. 2021 May;44(5):550-560. doi: 10.1038/s41440-020-00603-z. Epub 2021 Jan 14.

Abstract

Antihypertensive drugs remain one of the main beneficial strategies for cardiovascular disease prevention. The objective of our study was to investigate the associations of different clinical and socioeconomic (SES) factors, and the use of primary care medicine with treatment and adherence (proportion of days covered (PDC) by treatment) to hypertension management in French participants aware of their hypertension. Cross-sectional analyses of treatment for hypertension and adherence to treatment were performed using data from 396 participants from the ESTEBAN survey, a representative sample of the French population. Logistic regression analyses were performed to investigate associations between SES factors (age, sex, education, income, civil status), clinical factors, health care (general practitioner (GP) visits, cardiologist visits, number of consultations, home blood pressure measurement (HBPM)), treatment and adherence. A total of 265 of the 396 hypertensive patients were treated. Antihypertensive drug use was more common among elderly individuals (OR: 2.73 [1.14; 4.32), diabetic patients (OR: 4.18 [1.92; 6.44] and overweight hypertensive patients (OR = 3.04 [1.09; 4.99]). GP consultations and HBPM were associated with increased treatment (OR: 1.03 [1.01; 1.05]; OR: 1.97 [1.06; 2.61], respectively). The PDC was higher among men (p = 0.045) and couples living together (p = 0.018) but lower among diabetic patients (p = 0.012) and patients visiting a cardiologist (p = 0.008). Education and income levels were not associated with either treatment or the PDC. In France, SES factors seemed to have little impact on treatment and adherence to antihypertensive drug regimens. However, treatment administered by GPs and HBPM may play key roles in hypertension management. Although the PDC was quite low, both the number of GP consultations and HBPM were positively associated with pharmacological treatment.

摘要

抗高血压药物仍然是预防心血管疾病的主要有益策略之一。我们研究的目的是调查不同临床和社会经济(SES)因素,以及在知晓自己患有高血压的法国参与者中,使用基层医疗药物与高血压管理的治疗及依从性(治疗覆盖天数比例(PDC))之间的关联。利用来自ESTEBAN调查的396名参与者的数据,对高血压治疗和治疗依从性进行横断面分析,该调查是法国人口的代表性样本。进行逻辑回归分析以研究SES因素(年龄、性别、教育程度、收入、婚姻状况)、临床因素、医疗保健(全科医生(GP)就诊、心脏病专家就诊、会诊次数、家庭血压测量(HBPM))、治疗和依从性之间的关联。396名高血压患者中共有265人接受了治疗。抗高血压药物在老年人(比值比:2.73 [1.14;4.32])、糖尿病患者(比值比:4.18 [1.92;6.44])和超重高血压患者(比值比 = 3.04 [1.09;4.99])中使用更为常见。全科医生会诊和家庭血压测量分别与治疗增加相关(比值比:1.03 [1.01;1.05];比值比:1.97 [1.06;2.61])。男性(p = 0.045)和共同居住的夫妇(p = 0.018)的治疗覆盖天数比例较高,但糖尿病患者(p = 0.012)和就诊于心脏病专家的患者(p = 0.008)的比例较低。教育程度和收入水平与治疗或治疗覆盖天数比例均无关联。在法国,SES因素似乎对抗高血压药物治疗方案的治疗和依从性影响不大。然而全科医生进行的治疗和家庭血压测量可能在高血压管理中起关键作用。尽管治疗覆盖天数比例相当低,但全科医生会诊次数和家庭血压测量均与药物治疗呈正相关。

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