Department of Neurology, Center of Cerebrovascular Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
Department of Radiology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Biomark Med. 2021 Feb;15(2):87-96. doi: 10.2217/bmm-2019-0537. Epub 2021 Jan 14.
We aimed to investigate the influence of admission fibrinogen-to-albumin ratio (FAR) on 3-month outcomes after acute lacunar stroke. Consecutive patients with acute lacunar stroke were included and classified into two groups according to an optimized FAR cut-off value determined by receiver operating characteristic curve analysis. Compared with those with low FAR (<0.077), patients from the high FAR group (≥0.077) had significantly higher risk for 3-month disability and the composite outcome of death/disability. After logistic regression adjustment, high FAR was still significantly associated with 3-month disability and death/disability. FAR ≥0.077 on admission might be an independent predictor of disability and death/disability at 3 months after lacunar stroke, which needs to be verified in future studies.
我们旨在探讨入院纤维蛋白原/白蛋白比值（FAR）对急性腔隙性卒中后 3 个月结局的影响。连续纳入急性腔隙性卒中患者，并根据受试者工作特征曲线分析确定的优化 FAR 截断值将其分为两组。与 FAR 较低（<0.077）的患者相比，FAR 较高（≥0.077）的患者 3 个月时残疾和死亡/残疾的复合结局风险显著更高。经逻辑回归校正后，高 FAR 仍与 3 个月时残疾和死亡/残疾显著相关。入院时 FAR≥0.077可能是腔隙性卒中后 3 个月残疾和死亡/残疾的独立预测因子，这需要在未来的研究中进一步验证。
