Liu Changxia, Chen Li, Sun Dingming, Guo Yan, Zhu Honghong, Li Lei, Sun Shifu, He Guojun, Cheng Yongqing
Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu Province, 224000, People's Republic of China.
Department of Ophtalmology, Funing People's Hospital, Yancheng, Jiangsu Province, 224000, People's Republic of China.
J Inflamm Res. 2024 Dec 5;17:10441-10451. doi: 10.2147/JIR.S488600. eCollection 2024.
Inflammation plays a role in cerebral small vessel disease (CSVD) pathophysiology. This study aimed to explore the association of the fibrinogen-to-albumin ratio (FAR), a novel inflammatory marker, with CSVD burden in patients with transient ischemic attack (TIA).
From October 1, 2022, to November 30, 2023, continuous patients with TIA were recruited in the study. The total CSVD burden score and modified total CSVD burden score were used to assess the severity of CSVD. Multivariable regression analysis was used to explore the correlation between the FAR and CSVD in TIA patients.
A total of 455 participants were recruited, of whom 225 (48.35%), according to the total CSVD burden score, and 181 (40.67%), according to the modified CSVD burden score were finally identified as moderate-severe CSVD. Spearman correlation analysis showed that levels of FAR correlated with the total CSVD (r=0.392, P<0.001) and the modified total CSVD burden scores (r=0.379, P<0.001). Multivariable logistic regression analysis showed that FAR was independently associated with moderate-severe CSVD, both as a continuous variable and as a tertile variable (P<0.001).
The level of FAR on admission was independently associated with the severity of CSVD in patients with TIA.
炎症在脑小血管病（CSVD）的病理生理学中起作用。本研究旨在探讨一种新型炎症标志物纤维蛋白原与白蛋白比值（FAR）与短暂性脑缺血发作（TIA）患者CSVD负担之间的关联。
2022年10月1日至2023年11月30日，连续纳入TIA患者进行研究。采用总CSVD负担评分和改良总CSVD负担评分评估CSVD的严重程度。多变量回归分析用于探讨TIA患者中FAR与CSVD之间的相关性。
共招募了455名参与者，根据总CSVD负担评分，最终确定其中225名（48.35%），根据改良CSVD负担评分，181名（40.67%）为中重度CSVD。Spearman相关性分析显示，FAR水平与总CSVD（r=0.392，P<0.001）和改良总CSVD负担评分（r=0.379，P<0.001）相关。多变量逻辑回归分析显示，FAR作为连续变量和三分位数变量均与中重度CSVD独立相关（P<0.001）。
入院时FAR水平与TIA患者CSVD的严重程度独立相关。
