Department of Respiratory Sciences, University of Leicester, Leicester, UK.
Centre for Exercise and Rehabilitation Science, Institute for Lung Health, University Hospitals of Leicester NHS Trust, Leicester, UK.
Thorax. 2021 Jul;76(7):726-728. doi: 10.1136/thoraxjnl-2020-215949. Epub 2020 Dec 22.
Acute admission to hospital for an exacerbation of chronic respiratory disease (CRD) may impair skeletal muscle mass and function. We measured quadriceps thickness (Q), as a surrogate marker of muscle mass, at hospital admission, discharge, 6 weeks and 3 months in 55 patients with CRD. Q fell by 8.3% during the period of hospitalisation, which was sustained at 6 weeks, and only partially recovered at 3 months. Sustained loss was most marked in patients readmitted during the follow-up period. Acute reduction in quadriceps muscle mass occurs during hospitalisation, with prolonged and variable recovery, which is prevented with subsequent hospital readmission.
慢性呼吸疾病（CRD）急性加重住院可能会损害骨骼肌质量和功能。我们在 55 例 CRD 患者入院、出院、6 周和 3 个月时测量了股四头肌厚度（Q），作为肌肉质量的替代标志物。住院期间 Q 下降了 8.3%，6 周时持续下降，仅在 3 个月时部分恢复。在随访期间再次入院的患者中，持续丢失最为明显。股四头肌质量在住院期间急性减少，恢复时间延长且变化不定，随后再次住院可预防这种减少。
