State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Cell Immunol. 2021 Mar;361:104278. doi: 10.1016/j.cellimm.2020.104278. Epub 2020 Dec 31.
Organs and tissues contain a large number of tissue-resident macrophages (MΦ-Ts), which are essential for regulating homeostasis and ensuring a rapid response to injury. However, the environmental signals shaping MΦ-Ts phenotypes and the contribution of MΦ-Ts to pathological processes are just starting to be identified. MΦ-Ts isolated from aged animals or patients show alterations in morphology and distribution, defects in phagocytosis and autophagy, and loss of tissue-repair capacity. These variations are closely associated with age-associated disorders, such as inflammaging, which is characterized by cell senescence and a senescence-associated secretory phenotype (SASP) and is frequently observed in patients afflicted with chronic diseases. It seems that the role of these resident populations cannot be avoided in the treatment of aging-related diseases. This review will describe the mechanism by which MΦ-Ts support immune homeostasis and will then discuss how MΦ-Ts facilitate inflammaging and age-related diseases, which will be helpful in the development of new interventions and treatments for chronic diseases of the elderly.
器官和组织中含有大量组织驻留巨噬细胞（MΦ-Ts），它们对于调节内稳态和确保对损伤的快速反应至关重要。然而，目前才刚刚开始鉴定塑造 MΦ-Ts 表型的环境信号以及 MΦ-Ts 对病理过程的贡献。从老年动物或患者中分离出的 MΦ-Ts 在形态和分布上发生改变，吞噬作用和自噬作用缺陷，并丧失组织修复能力。这些变化与与年龄相关的疾病密切相关，例如炎症衰老，其特征是细胞衰老和衰老相关分泌表型（SASP），在患有慢性疾病的患者中经常观察到。似乎在治疗与衰老相关的疾病时，这些常驻群体的作用是不可避免的。这篇综述将描述 MΦ-Ts 支持免疫内稳态的机制，然后讨论 MΦ-Ts 如何促进炎症衰老和与年龄相关的疾病，这将有助于为老年慢性病的新干预和治疗方法的开发提供帮助。
