Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.
Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.
Curr Opin Cell Biol. 2021 Apr;69:23-29. doi: 10.1016/j.ceb.2020.12.011. Epub 2021 Jan 11.
Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct from each other, especially in the requirement of cargos for autophagosome formation. Recent studies revealed that liquid-like biomolecular condensates, which are formed through liquid-liquid phase separation, regulate the autophagosome formation of both bulk and selective autophagy. Here, we focus on recent findings on the involvement of biomolecular condensates in autophagy regulation and discuss their significance.
自噬是一种有助于细胞内稳态的细胞内降解系统。自噬体的形成是自噬的一个标志性事件，它将细胞质成分隔离并递送到溶酶体进行降解。根据选择性，自噬可以分为批量自噬和选择性自噬，它们在机制上彼此不同，特别是在自噬体形成所需的货物方面。最近的研究表明，通过液-液相分离形成的液态生物分子凝聚物调节批量自噬和选择性自噬的自噬体形成。在这里，我们重点介绍生物分子凝聚物在自噬调节中的最新发现，并讨论它们的意义。
