Woźniak-Budych Marta J, Przysiecka Łucja, Maciejewska Barbara M, Wieczorek Daria, Staszak Katarzyna, Jarek Marcin, Jesionowski Teofil, Jurga Stefan
NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Umultowska 85, Poznan 61-712, Poland.
Department of Technology and Instrumental Analysis, Faculty of Commodity Science, Poznan University of Economics and Business, al. Niepodległości 10, Poznan 61-875, Poland.
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3183-3194. doi: 10.1021/acsbiomaterials.7b00465. Epub 2017 Nov 7.
A novel approach using a zwitterionic sulfobetaine-based surfactant for the synthesis of spherical copper oxide nanoparticles (CuO NPs) has been applied. For the first time, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate has been used as stabilizer to control the size and morphology of CuO NPs. Several techniques, such as transmission electron microscopy (TEM), X-ray diffraction (XRD), and fluorescence spectroscopy, are used to investigate the size, structure, and optical properties of synthesized CuO nanocrystals. The results indicate that copper(I) oxide nanoparticles with size in the range of 2 to 45 nm and crystalline structure, exhibit intense yellow fluorescence (λ = 575 nm). Furthermore, the cytotoxicity studies show that sulfobetaine-stabilized copper oxide nanoparticles prompt inhibition of cancer cell proliferation in a concentration-dependent manner, however, the adverse effect on the normal cells has also been observed. The results indicate that the sulfobetaine-stabilized CuO, because of their unique properties, have a potential to be applied in medical fields, such as cancer therapy and bioimaging.
一种使用基于两性离子磺基甜菜碱的表面活性剂合成球形氧化铜纳米颗粒（CuO NPs）的新方法已被应用。首次使用N-十六烷基-N，N-二甲基-3-铵基-1-丙烷磺酸盐作为稳定剂来控制CuO NPs的尺寸和形态。采用了几种技术，如透射电子显微镜（TEM）、X射线衍射（XRD）和荧光光谱，来研究合成的CuO纳米晶体的尺寸、结构和光学性质。结果表明，尺寸在2至45nm范围内且具有晶体结构的氧化亚铜纳米颗粒呈现出强烈的黄色荧光（λ = 575nm）。此外，细胞毒性研究表明，磺基甜菜碱稳定的氧化铜纳米颗粒以浓度依赖的方式迅速抑制癌细胞增殖，然而，对正常细胞的不良影响也已被观察到。结果表明，磺基甜菜碱稳定的CuO因其独特的性质，有潜力应用于医学领域，如癌症治疗和生物成像。
