Jarraya Mohamed, Heiss Rafael, Duryea Jeffrey, Nagel Armin M, Lynch John A, Guermazi Ali, Weber Marc-André, Arkudas Andreas, Horch Raymund E, Uder Michael, Roemer Frank W
Department of Radiology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA.
Department of Radiology, Friedrich Alexander University Erlangen-Nürnberg (FAU) & Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Diagnostics (Basel). 2021 Jan 12;11(1):110. doi: 10.3390/diagnostics11010110.
Bone fractal signature analysis (FSA-also termed bone texture analysis) is a tool that assesses structural changes that may relate to clinical outcomes and functions. Our aim was to compare bone texture analysis of the distal radius in patients and volunteers using radiography and 3T and 7T magnetic resonance imaging (MRI)-a patient group ( = 25) and a volunteer group ( = 25) were included. Participants in the patient group had a history of chronic wrist pain with suspected or confirmed osteoarthritis and/or ligament instability. All participants had 3T and 7T MRI including T1-weighted turbo spin echo (TSE) sequences. The 7T MRI examination included an additional high-resolution (HR) T1 TSE sequence. Radiographs of the wrist were acquired for the patient group. When comparing patients and volunteers (unadjusted for gender and age), we found a statistically significant difference of horizontal and vertical fractal dimensions (FDs) using 7T T1 TSE-HR images in low-resolution mode (horizontal: = 0.04, vertical: = 0.01). When comparing radiography to the different MRI sequences, we found a statistically significant difference for low- and high-resolution horizontal FDs between radiography and 3T T1 TSE and 7T T1 TSE-HR. Vertical FDs were significantly different only between radiographs and 3T T1 TSE in the high-resolution mode; FSA measures obtained from 3T and 7T MRI are highly dependent on the sequence and reconstruction resolution used, and thus are not easily comparable between MRI systems and applied sequences.
骨分形特征分析（FSA，也称为骨纹理分析）是一种评估可能与临床结果和功能相关的结构变化的工具。我们的目的是比较患者和志愿者桡骨远端的骨纹理分析，采用X线摄影以及3T和7T磁共振成像（MRI）——纳入了一个患者组（n = 25）和一个志愿者组（n = 25）。患者组的参与者有慢性腕部疼痛病史，怀疑或确诊患骨关节炎和/或韧带不稳定。所有参与者均接受了3T和7T MRI检查，包括T1加权快速自旋回波（TSE）序列。7T MRI检查还包括一个额外的高分辨率（HR）T1 TSE序列。为患者组拍摄了腕部X线片。在比较患者和志愿者（未对性别和年龄进行调整）时，我们发现在低分辨率模式下使用7T T1 TSE - HR图像时，水平和垂直分形维数（FDs）存在统计学显著差异（水平：P = 0.04，垂直：P = 0.01）。在将X线摄影与不同的MRI序列进行比较时，我们发现X线摄影与3T T1 TSE和7T T1 TSE - HR之间在低分辨率和高分辨率水平FDs上存在统计学显著差异。垂直FDs仅在高分辨率模式下X线片与3T T1 TSE之间存在显著差异；从3T和7T MRI获得的FSA测量值高度依赖于所使用的序列和重建分辨率，因此在MRI系统和应用序列之间不易进行比较。
