多供应商多站点膝关节软骨 T2 和 T1ρ 定量分析。
Multi-vendor multi-site T and T quantification of knee cartilage.
机构信息
Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.
Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, OH, USA; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, OH, USA.
出版信息
Osteoarthritis Cartilage. 2020 Dec;28(12):1539-1550. doi: 10.1016/j.joca.2020.07.005. Epub 2020 Jul 30.
OBJECTIVE
To develop 3D T and T imaging based on the same sequence structure on MR systems from multiple vendors, and to evaluate intra-site repeatability and inter-site inter-vendor reproducibility of T and T measurements of knee cartilage.
METHODS
3D magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (3D MAPSS) were implemented on MR systems from Siemens, GE and Philips. Phantom and human subject data were collected at four sites using 3T MR systems from the three vendors with harmonized protocols. Phantom data were collected by means of different positioning of the coil. Volunteers were scanned and rescanned after repositioning. Two traveling volunteers were scanned at all sites. Data were transferred to one site for centralized processing.
RESULTS
Intra-site average coefficient of variations (CVs) ranged from 1.09% to 3.05% for T and 1.78-3.30% for T in phantoms, and 1.60-3.93% for T and 1.44-4.08% for T in volunteers. Inter-site average CVs were 5.23% and 6.45% for MAPSS T and T, respectively in phantoms, and 8.14% and 10.06% for MAPSS T and T, respectively, In volunteers.
CONCLUSION
This study showed promising results of multi-site, multi-vendor reproducibility of T and T values in knee cartilage. These quantitative measures may be applied in large-scale multi-site, multi-vendor trials with controlled sequence structure and scan parameters and centralized data processing.
目的
基于来自不同供应商的磁共振系统上相同的序列结构，开发 3D T1 和 T2 成像，并评估膝关节软骨 T1 和 T2 测量的同站内重复性和站间跨供应商可重复性。
方法
在西门子、GE 和飞利浦的磁共振系统上实现了 3D 磁化准备角调制分区 K 空间扰相梯度回波快照（3D MAPSS）。使用来自这三个供应商的 3T 磁共振系统，在四个站点采集了体模和人体志愿者数据，并采用协调的方案。通过改变线圈的位置采集体模数据。志愿者在重新定位后进行扫描和再扫描。两名流动志愿者在所有站点进行扫描。数据被传输到一个站点进行集中处理。
结果
在体模中，T1 和 T2 的同站内平均变异系数（CV）范围为 1.09%-3.05%和 1.78%-3.30%，志愿者的 T1 和 T2 的同站内平均 CV 分别为 1.60%-3.93%和 1.44%-4.08%。在体模中，MAPSS T1 和 T2 的站间平均 CV 分别为 5.23%和 6.45%，志愿者的 MAPSS T1 和 T2 的站间平均 CV 分别为 8.14%和 10.06%。
结论
本研究表明，在膝关节软骨中，多站点、多供应商的 T1 和 T2 值具有很好的可重复性。这些定量指标可应用于具有受控序列结构和扫描参数的大型多站点、多供应商试验，并进行集中数据处理。
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