费希尔344大鼠中的脊索瘤。

Chordomas in Fischer 344 rats.

作者信息

Stefanski S A, Elwell M R, Mitsumori K, Yoshitomi K, Dittrich K, Giles H D

机构信息

Chemical Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.

出版信息

Vet Pathol. 1988 Jan;25(1):42-7. doi: 10.1177/030098588802500106.

DOI:10.1177/030098588802500106

PMID:3344569

Abstract

Tissue sections and records of 56 rats with chordoma, identified in the National Toxicology Program's (NTP) data base of approximately 115,000 rats, were examined to determine morphological characteristics, incidence, and aspects of biological behavior. Chordomas occurred in aged rats, originated predominantly in lumbosacral vertebrae, were highly malignant, occurred three times more often in male versus female rats, and commonly produced bilateral posterior paresis, paralysis, and/or distention of the colon and rectum.

摘要

在国家毒理学计划（NTP）约115,000只大鼠的数据库中识别出56只患有脊索瘤的大鼠，对其组织切片和记录进行检查，以确定形态学特征、发病率及生物学行为方面的情况。脊索瘤发生于老年大鼠，主要起源于腰骶椎，恶性程度高，雄性大鼠的发生率是雌性大鼠的三倍，并且通常会导致双侧后肢轻瘫、瘫痪和/或结肠及直肠扩张。