Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Naples, Italy.
Institute of Sciences of Food Production (ISPA), National Research Council, Bari, Italy.
Nat Prod Res. 2022 Mar;36(5):1253-1259. doi: 10.1080/14786419.2021.1872570. Epub 2021 Jan 15.
Since 1987, several cytochalasins were isolated from var. , the causal agent of foliar blight disease of oleander ( L.), and chemically and biologically characterised. During the purification process of a large-scale production of cytochalasins A and B, necessary to continue the study on their anticancer activity, a metabolite having a different carbon skeleton compared to that of cytochalasans, was isolated. It was identified as terpestacin, a well-known toxic fungal stestertepenoid, isolated for the first time from var. , by spectroscopic investigation (essentially 1D and 2D H and C-NMR and ESI MS) and optical methods in comparison with the literature data. Terpestacin and some its derivatives (including a natural one, fusaproliferin) were prepared and tested for their biological activity. Terpestacin and fusaproliferin had some inhibitory effects on seed germination of , whereas none of the compounds caused phytotoxic effects on weed leaves.[Formula: see text].
自 1987 年以来，已从引起夹竹桃叶斑病的病原菌中分离到几种细胞松弛素，并对其进行了化学和生物学表征。在进行细胞松弛素 A 和 B 的大规模生产纯化过程中，需要继续研究其抗癌活性，分离出一种与细胞松弛素具有不同碳骨架的代谢产物。通过光谱研究（主要是 1D 和 2D H 和 C-NMR 以及 ESI MS）和与文献数据的比较，将其鉴定为萜烯毒素，这是一种众所周知的真菌甾体类化合物，首次从 var.中分离出来。萜烯毒素及其一些衍生物（包括一种天然产物，呋甾醇）已被制备并测试其生物活性。萜烯毒素和呋甾醇对 的种子萌发有一定的抑制作用，而这些化合物对杂草叶片均无植物毒性作用。
