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层特异性应变评估柚皮苷对脓毒症引起的收缩性心肌功能障碍的影响及其潜在机制。

Layer-specific strain for assessing the effect of naringin on systolic myocardial dysfunction induced by sepsis and its underlying mechanisms.

机构信息

Department of Ultrasound, First Hospital of Qinhuangdao, Qinhuangdao, P.R. China.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, P.R. China.

出版信息

J Int Med Res. 2021 Jan;49(1):300060520986369. doi: 10.1177/0300060520986369.

DOI:10.1177/0300060520986369
PMID:33445988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7812414/
Abstract

OBJECTIVE

This study aimed to investigate the protective effects of naringin on myocardial deformation and oxidative responses in rats with sepsis-induced myocardial dysfunction (SIMD).

METHODS

Global and segmental layer-specific longitudinal strain (LS) was assessed by speckle tracking echocardiography. Serum levels of creatine kinase, lactate dehydrogenase, superoxide dismutase, and malondialdehyde were measured. The activity of cleaved caspase-3 was determined by immunohistochemistry. Protein expression levels of Kelch-like ECH-related protein 1 (Keap1), nuclear erythroid factor 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were measured by western blotting.

RESULTS

Naringin inhibited the lipopolysaccharide-induced decrease in global and layer-specific LS of the left ventricle. Naringin also increased superoxide dismutase expression and decreased malondialdehyde, creatine kinase, lactate dehydrogenase, and cleaved caspase-3 expression in rats with SIMD. Furthermore, naringin increased Nrf2 and HO-1 protein expression levels, and decreased Keap1 protein expression levels in rats with SIMD.

CONCLUSION

Layer-specific LS analysis of myocardial function by speckle tracking echocardiography can reflect early changes in myocardial systolic function. Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.

摘要

目的

本研究旨在探讨柚皮苷对脓毒症诱导的心肌功能障碍（SIMD）大鼠心肌变形和氧化反应的保护作用。

方法

采用斑点追踪超声心动图评估整体和节段层特异性纵向应变（LS）。测量血清肌酸激酶、乳酸脱氢酶、超氧化物歧化酶和丙二醛水平。通过免疫组织化学测定裂解半胱氨酸天冬氨酸蛋白酶-3（caspase-3）的活性。通过 Western blot 测定 Kelch 样 ECH 相关蛋白 1（Keap1）、核红细胞因子 2 相关因子 2（Nrf2）和血红素加氧酶-1（HO-1）的蛋白表达水平。

结果

柚皮苷抑制了脂多糖诱导的左心室整体和节段层特异性 LS 的下降。柚皮苷还增加了 SIMD 大鼠中超氧化物歧化酶的表达，降低了丙二醛、肌酸激酶、乳酸脱氢酶和裂解 caspase-3 的表达。此外，柚皮苷增加了 SIMD 大鼠中 Nrf2 和 HO-1 的蛋白表达水平，并降低了 Keap1 的蛋白表达水平。

结论

通过斑点追踪超声心动图对心肌功能的层特异性 LS 分析可以反映心肌收缩功能的早期变化。柚皮苷可能通过 Keap1/Nrf2/HO-1 通路调节脂多糖诱导的心肌氧化应激，从而对 SIMD 大鼠具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/31f3db5da61e/10.1177_0300060520986369-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/dee21833fd86/10.1177_0300060520986369-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/2430bc8dc020/10.1177_0300060520986369-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/4d150379ce22/10.1177_0300060520986369-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/71c3b97b9a2d/10.1177_0300060520986369-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/764f98924aa3/10.1177_0300060520986369-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/d4a625cee55a/10.1177_0300060520986369-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/31f3db5da61e/10.1177_0300060520986369-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/dee21833fd86/10.1177_0300060520986369-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/2430bc8dc020/10.1177_0300060520986369-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/4d150379ce22/10.1177_0300060520986369-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/71c3b97b9a2d/10.1177_0300060520986369-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/764f98924aa3/10.1177_0300060520986369-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/d4a625cee55a/10.1177_0300060520986369-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06b3/7812414/31f3db5da61e/10.1177_0300060520986369-fig7.jpg

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