Department of Health Management & Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
J Int Med Res. 2021 Jan;49(1):300060520986311. doi: 10.1177/0300060520986311.
Metabolic syndrome (MetS) involves multiple metabolic disorders and seriously affects human health. Identification of key biological factors associated with MetS incidence is therefore important. We explored the association between MetS and the biochemical profiles of Chinese adults in Shenyang City in a nested case-control study.
We included adult participants who underwent physical examination at our hospital for 2 consecutive years. Participants' biochemical profiles and other MetS components were tested and monitored continuously. Propensity score matching was used to adjust confounding factors between participants with and without MetS. We analyzed the association between incidence of MetS and the biochemical profiles of participants.
Of 5702 participants who underwent physical examination between 1 January 2017 and 1 December 2018, 538 had confirmed newly developed MetS. After successfully matching 436 pairs of participants, mean cystatin C (Cys-C) level was significantly higher in the MetS group than in the non-MetS group. Logistic regression analysis indicated that age (years) and γ-glutamate transpeptidase, creatinine, uric acid, and Cys-C levels were significantly associated with MetS incidence; among these, the odds ratio of Cys-C was highest (3.03; 95% confidence interval, 1.02-9.00).
Cys-C levels were significantly associated with the incidence of MetS among Chinese adults.
代谢综合征（MetS）涉及多种代谢紊乱，严重影响人类健康。因此，确定与 MetS 发病相关的关键生物学因素非常重要。我们在一项巢式病例对照研究中探讨了代谢综合征与沈阳市成年人群生化特征之间的关系。
我们纳入了连续两年在我院进行体检的成年参与者。连续监测参与者的生化特征和其他 MetS 成分。采用倾向性评分匹配调整有和无 MetS 参与者之间的混杂因素。我们分析了 MetS 发生率与参与者生化特征之间的关系。
在 2017 年 1 月 1 日至 2018 年 12 月 1 日期间接受体检的 5702 名参与者中，有 538 人确诊为新发 MetS。成功匹配 436 对参与者后，MetS 组的胱抑素 C（Cys-C）水平明显高于非 MetS 组。Logistic 回归分析表明，年龄（岁）和γ-谷氨酰转肽酶、肌酐、尿酸和 Cys-C 水平与 MetS 发病显著相关；其中 Cys-C 的比值比最高（3.03；95%置信区间，1.02-9.00）。
Cys-C 水平与中国成年人代谢综合征的发病显著相关。
