Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Pwllpeiran, Cwmystwyth, Aberystwyth, SY23 4AB, UK.
Royal Agricultural University, Stroud Rd, Cirencester, Gloucestershire, GL7 6JS, UK.
Sci Rep. 2021 Jan 14;11(1):1389. doi: 10.1038/s41598-021-81042-9.
Alzheimer's disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine Narcissus-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of Narcissus pseudonarcissus sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of N. pseudonarcissus was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of N. pseudonarcissus cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of N. pseudonarcissus into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.
阿尔茨海默病（AD）是一种与记忆和认知功能进行性退化相关的疾病。加兰他敏是一种获准用于 AD 的治疗药物，但它所来源于的植物生物碱加兰他敏的供应有限。这项为期三年的系统研究测试了将水仙衍生的加兰他敏生产与基于草原的反刍动物生产相结合的潜力。准备了带有和不带有水仙鳞茎播种成行的永久性草地的重复地块。施加了两种不同的施肥制度。早春收获水仙的地上绿色生物量，并确定加兰他敏的产量。在第二年的收获中，采用水仙行每年和每两年一次切割的裂区设计。随后所有地块都被母羊和羔羊放牧，并记录动物的表现。将水仙纳入放牧的永久性草地中，对随后放牧该草地的绵羊的健康或表现没有不利影响。施肥率对加兰他敏产量的影响没有一致性。如果水仙每两年（每年和两年分别为 1.64 公斤和 1.75 公斤水仙/公顷）切割，总加兰他敏产量没有差异；标准误差差异（s.e.d）= 0.117 公斤加兰他敏/公顷；无显著差异（ns）。这项研究验证了双重种植方法生产植物衍生的加兰他敏的可行性。
