Sallon S, Deckelbaum R J, Schmid I I, Harlap S, Baras M, Spira D T
Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Am J Dis Child. 1988 Mar;142(3):312-5. doi: 10.1001/archpedi.1988.02150030086027.
Cryptosporidium was found in the stools of 13.5% of 221 children hospitalized with diarrhea. It was the single most prevalent pathogen isolated. Children with Cryptosporidium-positive stools were significantly more malnourished than children in whom Cryptosporidium was not detected. Children with more severe malnutrition (ie, less than 50% of their expected weight) and with Cryptosporidium in their stools had a significantly longer duration of diarrhea than similarly malnourished children without Cryptosporidium (63 vs 32 days, respectively). In 77 better-nourished outpatients with diarrhea, Cryptosporidium was found in only 5.2% of cases and was associated with less-severe illness. Our findings are consistent with the hypothesis that in less-developed areas, Cryptosporidium is a major pathogen, not only in acute but also in chronic childhood diarrhea, and may play an important role in the interaction between diarrhea and malnutrition.
在221名因腹泻住院的儿童中，13.5%的儿童粪便中发现了隐孢子虫。它是分离出的最常见的单一病原体。粪便隐孢子虫检测呈阳性的儿童比未检测到隐孢子虫的儿童营养不良得多。患有更严重营养不良（即体重不足预期体重的50%）且粪便中有隐孢子虫的儿童腹泻持续时间明显长于同样营养不良但无隐孢子虫的儿童（分别为63天和32天）。在77名营养状况较好的腹泻门诊患者中，仅5.2%的病例发现了隐孢子虫，且病情较轻。我们的研究结果与以下假设一致：在欠发达地区，隐孢子虫不仅是儿童急性腹泻的主要病原体，也是慢性腹泻的主要病原体，并且可能在腹泻与营养不良的相互作用中发挥重要作用。
