基于炎症的预后评分对下咽鳞状细胞癌患者生存的影响
Impacts of Inflammation-Based Prognostic Scores on Survival in Patients With Hypopharyngeal Squamous Cell Carcinoma.
作者信息
Iuchi Hiroyuki, Kyutoku Takayuki, Ito Kotoko, Matsumoto Hayato, Ohori Junichiro, Yamashita Masaru
机构信息
Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan.
出版信息
OTO Open. 2020 Dec 29;4(4):2473974X20978137. doi: 10.1177/2473974X20978137. eCollection 2020 Oct-Dec.
OBJECTIVE
To investigate the predictive accuracies of the modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) as prognostic factors for patients with hypopharyngeal squamous cell carcinoma (HSCC).
STUDY DESIGN
Retrospective study.
SETTING
University hospital.
METHODS
The records of 106 patients who were histologically diagnosed with HSCC between January 2007 and December 2017 were reviewed. mGPS, NLR, and PLR were analyzed; univariate and multivariate analyses were performed to evaluate the prognosis of overall survival (OS).
RESULTS
The overall 5-year survival rates of patients with mGPS0, mGPS1, and mGPS2 were 82.0%, 41.9%, and 13.5%, respectively. The overall 5-year survival rates of patients with low and high NLRs and with low and high PLRs were 83.8%, 46.2%, 57.0%, and 59.1%, respectively. mGPS ( < .001) and NLR ( < .05) were independently associated with OS, whereas PLR was not. For stage IV HSCC, only mGPS was independently associated with OS ( = .004).
CONCLUSION
mGPS is an excellent prognostic factor for patients with HSCC.
目的
探讨改良格拉斯哥预后评分（mGPS）、中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）作为下咽鳞状细胞癌（HSCC）患者预后因素的预测准确性。
研究设计
回顾性研究。
研究地点
大学医院。
方法
回顾性分析2007年1月至2017年12月间106例经组织学诊断为HSCC患者的病历。分析mGPS、NLR和PLR；进行单因素和多因素分析以评估总生存期（OS）的预后。
结果
mGPS 0、mGPS 1和mGPS 2患者的5年总生存率分别为82.0%、41.9%和13.5%。NLR低和高以及PLR低和高的患者的5年总生存率分别为83.8%、46.2%、57.0%和59.1%。mGPS（<.001）和NLR（<.05）与OS独立相关，而PLR则不然。对于IV期HSCC，只有mGPS与OS独立相关（=.004）。
结论
mGPS是HSCC患者的一个优秀预后因素。
Zotero 插件