College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071, P. R. China.
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, 266100, P. R. China.
Small. 2021 Feb;17(5):e2005578. doi: 10.1002/smll.202005578. Epub 2021 Jan 15.
Fluorescent nanomaterials have exhibited promising applications in biomedical and tissue engineering fields. To improve the properties and expand bioapplications of fluorescent nanomaterials, various functionalization and biomodification strategies have been utilized to engineer the structure and function of fluorescent nanomaterials. Due to their high biocompatibility, satisfied bioactivity, unique biomimetic function, easy structural tailoring, and controlled self-assembly ability, supramolecular peptides are widely used as versatile modification agents and nanoscale building blocks for engineering fluorescent nanomaterials. In this work, recent advance in the synthesis, structure, function, and biomedical applications of peptide-engineered fluorescent nanomaterials is presented. Firstly, the types of different fluorescent nanomaterials are introduced. Then, potential strategies for the preparation of peptide-engineered fluorescent nanomaterials via templated synthesis, bioinspired conjugation, and peptide assembly-assisted synthesis are discussed. After that, the unique structure and functions through the peptide conjugation with fluorescent nanomaterials are demonstrated. Finally, the biomedical applications of peptide-engineered fluorescent nanomaterials in bioimaging, disease diagnostics and therapy, drug delivery, tissue engineering, antimicrobial test, and biosensing are presented and discussed in detail. It is helpful for readers to understand the peptide-based conjugation and bioinspired synthesis of fluorescent nanomaterials, and to design and synthesize novel hybrid bionanomaterials with special structures and improved functions for advanced applications.
荧光纳米材料在生物医学和组织工程领域表现出了有前景的应用。为了改善荧光纳米材料的性能并扩展其生物应用，人们利用各种功能化和生物修饰策略来设计荧光纳米材料的结构和功能。由于具有高生物相容性、满意的生物活性、独特的仿生功能、易于结构剪裁和可控的自组装能力，超分子肽被广泛用作工程化荧光纳米材料的通用修饰剂和纳米级构建块。在这项工作中，介绍了肽工程荧光纳米材料的合成、结构、功能和生物医学应用的最新进展。首先，介绍了不同荧光纳米材料的类型。然后，讨论了通过模板合成、仿生偶联和肽组装辅助合成制备肽工程荧光纳米材料的潜在策略。接着，展示了通过肽与荧光纳米材料的偶联获得的独特结构和功能。最后，详细介绍和讨论了肽工程荧光纳米材料在生物成像、疾病诊断和治疗、药物传递、组织工程、抗菌测试和生物传感等生物医学领域的应用。这有助于读者理解基于肽的荧光纳米材料的偶联和仿生合成，并设计和合成具有特殊结构和改进功能的新型杂化生物纳米材料，以用于高级应用。
