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多功能荧光聚合物纳米材料的设计、合成及生物医学应用。

Design, Synthesis, and Biomedical Application of Multifunctional Fluorescent Polymer Nanomaterials.

机构信息

School of Life Science, Changchun Normal University, Changchun 130032, China.

School of Education, Changchun Normal University, Changchun 130032, China.

出版信息

Molecules. 2023 Apr 29;28(9):3819. doi: 10.3390/molecules28093819.

DOI:10.3390/molecules28093819
PMID:37175229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10179976/
Abstract

Luminescent polymer nanomaterials not only have the characteristics of various types of luminescent functional materials and a wide range of applications, but also have the characteristics of good biocompatibility and easy functionalization of polymer nanomaterials. They are widely used in biomedical fields such as bioimaging, biosensing, and drug delivery. Designing and constructing new controllable synthesis methods for multifunctional fluorescent polymer nanomaterials with good water solubility and excellent biocompatibility is of great significance. Exploring efficient functionalization methods for luminescent materials is still one of the core issues in the design and development of new fluorescent materials. With this in mind, this review first introduces the structures, properties, and synthetic methods regarding fluorescent polymeric nanomaterials. Then, the functionalization strategies of fluorescent polymer nanomaterials are summarized. In addition, the research progress of multifunctional fluorescent polymer nanomaterials for bioimaging is also discussed. Finally, the synthesis, development, and application fields of fluorescent polymeric nanomaterials, as well as the challenges and opportunities of structure-property correlations, are comprehensively summarized and the corresponding perspectives are well illustrated.

摘要

发光聚合物纳米材料不仅具有多种类型发光功能材料的特性和广泛的应用，而且还具有良好的生物相容性和聚合物纳米材料易于功能化的特点。它们被广泛应用于生物医学领域，如生物成像、生物传感和药物输送。设计和构建具有良好水溶性和优异生物相容性的多功能荧光聚合物纳米材料的可控合成方法具有重要意义。探索发光材料的有效功能化方法仍然是新型荧光材料设计和开发的核心问题之一。有鉴于此，本综述首先介绍了荧光聚合物纳米材料的结构、性质和合成方法。然后，总结了荧光聚合物纳米材料的功能化策略。此外，还讨论了用于生物成像的多功能荧光聚合物纳米材料的研究进展。最后，全面总结了荧光聚合物纳米材料的合成、发展和应用领域，以及结构-性能相关性的挑战和机遇，并很好地说明了相应的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/29d2aa052a09/molecules-28-03819-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/c05d0fb6425f/molecules-28-03819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/aa31bc3cc567/molecules-28-03819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/0e923f962c0d/molecules-28-03819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/b86c1a9ad1ec/molecules-28-03819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/48bf83fd20e8/molecules-28-03819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/a637613b23ba/molecules-28-03819-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/9f17a81a62d3/molecules-28-03819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/5e24ca81cdd0/molecules-28-03819-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/9bed111d6ae5/molecules-28-03819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/1a49f6c9e16a/molecules-28-03819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/b09a3baacdcd/molecules-28-03819-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/93f23fe426e4/molecules-28-03819-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/db4a2e6f888b/molecules-28-03819-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/97b461d7a571/molecules-28-03819-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/116ed00e95f0/molecules-28-03819-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/7e2177a485de/molecules-28-03819-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/06582f5f9f75/molecules-28-03819-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/1e14f04bc085/molecules-28-03819-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/0ba7af6b1dfa/molecules-28-03819-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/29d2aa052a09/molecules-28-03819-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/c05d0fb6425f/molecules-28-03819-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/aa31bc3cc567/molecules-28-03819-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/0e923f962c0d/molecules-28-03819-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/b86c1a9ad1ec/molecules-28-03819-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/48bf83fd20e8/molecules-28-03819-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/a637613b23ba/molecules-28-03819-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/9f17a81a62d3/molecules-28-03819-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/5e24ca81cdd0/molecules-28-03819-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/9bed111d6ae5/molecules-28-03819-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/1a49f6c9e16a/molecules-28-03819-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/b09a3baacdcd/molecules-28-03819-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/93f23fe426e4/molecules-28-03819-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/db4a2e6f888b/molecules-28-03819-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/97b461d7a571/molecules-28-03819-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/116ed00e95f0/molecules-28-03819-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/7e2177a485de/molecules-28-03819-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/06582f5f9f75/molecules-28-03819-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/1e14f04bc085/molecules-28-03819-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/0ba7af6b1dfa/molecules-28-03819-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/446d/10179976/29d2aa052a09/molecules-28-03819-g020.jpg

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