Department of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.
Brain Behav. 2021 May;11(5):e02035. doi: 10.1002/brb3.2035. Epub 2021 Jan 15.
Investigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how this feature aligns with neurodegeneration elsewhere in the brain, specifically in early disease stages.
Using optical coherence tomography and magnetic resonance imaging, we examined retinal thickness as well as hippocampal structure in patients with amnestic mild cognitive impairment and healthy controls.
The groups did not differ in hippocampal and retinal thickness measures. However, we detected a correlation of peripapillary retinal nerve fiber layer thickness and hippocampal thickness in healthy people but not in cognitively impaired patients. The ratio of hippocampus to retina thickness was significantly smaller in patients with mild cognitive impairment and correlated positively with cognitive performance.
Different temporal trajectories of neurodegeneration may disrupt transregional brain structure associations in patients with amnestic mild cognitive impairment.
研究视网膜厚度可能有助于补充痴呆症和其他神经退行性疾病的现有生物学标志物。虽然视网膜变薄与认知能力下降相关，但仍需研究这种特征与大脑其他部位的神经退行性变（特别是在疾病早期阶段）是否以及如何相关。
我们使用光学相干断层扫描和磁共振成像技术，检查了遗忘型轻度认知障碍患者和健康对照组的视网膜厚度和海马结构。
两组在海马和视网膜厚度测量方面没有差异。然而，我们在健康人群中检测到视盘周围视网膜神经纤维层厚度和海马厚度之间存在相关性，但在认知障碍患者中则没有。轻度认知障碍患者的海马与视网膜厚度比显著较小，并且与认知表现呈正相关。
不同的神经退行性变时间轨迹可能会破坏遗忘型轻度认知障碍患者的跨区域脑结构关联。
