Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands.
Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, 9713 AV, the Netherlands; Laboratory of Molecular and Cellular Biology (LIM15), Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Biochim Biophys Acta Mol Cell Res. 2021 Apr;1868(4):118965. doi: 10.1016/j.bbamcr.2021.118965. Epub 2021 Jan 13.
Coenzyme A (CoA) is a key molecule in cellular metabolism including the tricarboxylic acid cycle, fatty acid synthesis, amino acid synthesis and lipid metabolism. Moreover, CoA is required for biological processes like protein post-translational modifications (PTMs) including acylation. CoA levels affect the amount of histone acetylation and thereby modulate gene expression. A direct influence of CoA levels on other PTMs, like CoAlation and 4'-phosphopantetheinylation has been relatively less addressed and will be discussed here. Increased CoA levels are associated with increased CoAlation, whereas decreased 4'-phosphopantetheinylation is observed under circumstances of decreased CoA levels. We discuss how these two PTMs can positively or negatively influence target proteins depending on CoA levels. This review highlights the impact of CoA levels on post-translational modifications, their counteractive interplay and the far-reaching consequences thereof.
辅酶 A（CoA）是细胞代谢中的关键分子，包括三羧酸循环、脂肪酸合成、氨基酸合成和脂质代谢。此外，CoA 还需要参与蛋白质翻译后修饰（PTMs）等生物过程，包括酰化。CoA 水平会影响组蛋白乙酰化的程度，从而调节基因表达。CoA 水平对其他 PTMs（如 CoAlation 和 4'-磷酸泛酰巯基乙胺化）的直接影响相对较少，本文将对此进行讨论。CoA 水平升高与 CoAlation 增加有关，而 CoA 水平降低时则观察到 4'-磷酸泛酰巯基乙胺化减少。我们讨论了这两种 PTMs 如何根据 CoA 水平，对靶蛋白产生正向或负向影响。本文综述了 CoA 水平对翻译后修饰的影响、它们的相互拮抗作用及其深远的后果。
