Greenspon L W, Levy S F
Pulmonary Disease Section, the Medical College of Pennsylvania, Philadelphia 19129.
Am Rev Respir Dis. 1988 Mar;137(3):722-5. doi: 10.1164/ajrccm/137.3.722.
Calcium antagonists, like verapamil, may play a beneficial role in the management of airway disease. However, the effect that verapamil plays in modulating the response to beta-adrenergic bronchodilator therapy has not been well characterized. We found that inhaled verapamil, 3 mg, had little effect on the bronchodilator response to sequential inhalations of isoproterenol. Also, verapamil had no significant effect on isoproterenol's protection against methacholine-induced bronchospasm in a group of 8 mild asthmatics. These studies support the safe use of these agents in combination but do not demonstrate any additive or synergistic benefit.
钙拮抗剂，如维拉帕米，可能在气道疾病的治疗中发挥有益作用。然而，维拉帕米在调节对β-肾上腺素能支气管扩张剂治疗反应方面所起的作用尚未得到充分阐明。我们发现，吸入3毫克维拉帕米对异丙肾上腺素连续吸入的支气管扩张反应几乎没有影响。此外，在一组8名轻度哮喘患者中，维拉帕米对异丙肾上腺素预防乙酰甲胆碱诱发的支气管痉挛也没有显著作用。这些研究支持联合使用这些药物的安全性，但未显示出任何相加或协同益处。
