Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.
Department of Biology, University of Pisa, 56127 Pisa, Italy.
Int J Mol Sci. 2021 Jan 13;22(2):726. doi: 10.3390/ijms22020726.
Lipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol content involved in diverse cellular processes. They have been proposed to influence membrane properties and to accommodate receptors within themselves by facilitating their interaction with ligands. Over the past decade, technical advances have improved our understanding of lipid rafts as bioactive structures. In this review, we will cover the more recent findings about cholesterol, sphingolipids and lipid rafts located in cellular and nuclear membranes in cancer. Collectively, the data provide insights on the role of lipid rafts as biomolecular targets in cancer with good perspectives for the development of innovative therapeutic strategies.
脂质筏是细胞膜脂质平台中的关键成分，富含神经酰胺和胆固醇，参与多种细胞过程。它们被认为通过促进与其配体的相互作用来影响膜特性并容纳自身受体。在过去的十年中，技术的进步提高了我们对脂质筏作为生物活性结构的理解。在这篇综述中，我们将介绍关于癌症中细胞膜和核膜中胆固醇、鞘脂和脂质筏的最新发现。总的来说，这些数据提供了有关脂质筏作为癌症中生物分子靶标的作用的见解，为开发创新的治疗策略提供了良好的前景。
