Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Department of Epidemiology and Biostatistics, School of Health and Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Sci Rep. 2021 Jan 15;11(1):1548. doi: 10.1038/s41598-020-79707-y.
Comorbidities are common in chronic obstructive pulmonary disease (COPD) patients. This study was conducted to determine the prevalence of common comorbidities in patients with COPD compared with people without COPD. This cross-sectional, population-based study was performed on 6961 adults aged 35-70 years enrolled in the Shahrekord PERSIAN cohort study. Data (demographic and clinical characteristics, comorbidities, anthropometric and blood pressure measurements, laboratory, and spirometry tests) collection was performed according to the cohort protocol from 2015 to 2019. In the present study, 215 (3.1%) patients were diagnosed with COPD and 1753 (25.18%) ones with restrictive lung patterns. The mean age of COPD patients was 52.5 ± 9.76 years. 55.8% of patients were male, 17.7% were current smokers and 12.1% had a history of smoking or were former smokers. 5.6% of patients had no comorbidity and 94.5% had at least one comorbidity. The most common comorbidities in COPD patients were dyslipidemia (70.2%), hypertension (30.2%), metabolic syndrome (22.8%), and diabetes (16.7%). The most common comorbidities in individuals with a restrictive spirometry pattern were dyslipidemia (68.9%), metabolic syndrome (27.2%), hypertension (26.1%), depression (17.6%), and fatty liver (15.5%). The logistic regression analysis with 95% confidence interval (95%CI) of odds ratio (OR) showed that comorbidities of chronic lung diseases (OR = 2.12, 95% CI 1.30-3.44), diabetes (OR = 1.54, 95%CI 1.03-2.29), cardiovascular disease (OR = 1.52, 95%CI 1.17-2.43), and hypertension (OR = 1.4, 95%CI 1.02-1.99) were more likely to occur in COPD patients than in healthy individuals. Knowing these prevalence rates and related information provides new insights on comorbidities to reduce disease burden and develop preventive interventions and to regulate health care resources to meet the needs of patients in primary health care.
在慢性阻塞性肺疾病（COPD）患者中，合并症很常见。本研究旨在确定与无 COPD 患者相比，COPD 患者常见合并症的患病率。这是一项横断面、基于人群的研究，共纳入了 6961 名年龄在 35-70 岁的成年人，他们参加了 Shahrekord PERSIAN 队列研究。数据（人口统计学和临床特征、合并症、人体测量和血压测量、实验室和肺功能检查）是根据队列方案从 2015 年到 2019 年收集的。在本研究中，215 名（3.1%）患者被诊断为 COPD，1753 名（25.18%）患者存在限制性肺模式。COPD 患者的平均年龄为 52.5±9.76 岁。55.8%的患者为男性，17.7%为当前吸烟者，12.1%有吸烟史或曾为吸烟者。5.6%的患者无合并症，94.5%的患者至少有一种合并症。COPD 患者最常见的合并症是血脂异常（70.2%）、高血压（30.2%）、代谢综合征（22.8%）和糖尿病（16.7%）。在存在限制性肺功能模式的个体中，最常见的合并症是血脂异常（68.9%）、代谢综合征（27.2%）、高血压（26.1%）、抑郁（17.6%）和脂肪肝（15.5%）。95%置信区间（95%CI）的优势比（OR）的逻辑回归分析显示，慢性肺部疾病（OR=2.12，95%CI 1.30-3.44）、糖尿病（OR=1.54，95%CI 1.03-2.29）、心血管疾病（OR=1.52，95%CI 1.17-2.43）和高血压（OR=1.4，95%CI 1.02-1.99）的合并症在 COPD 患者中比在健康个体中更常见。了解这些患病率和相关信息，为减少疾病负担和制定预防干预措施提供了新的见解，并为满足初级保健患者的医疗保健资源需求提供了新的见解。
