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JAK inhibitors and VTE risk: how concerned should we be?

作者信息

Cohen Stanley B

机构信息

Metroplex Clinical Research Center, Rheumatology Department, THR Presbyterian Hospital, Dallas, TX, USA.

University of Texas Southwestern Medical School, Dallas, TX, USA.

出版信息

Nat Rev Rheumatol. 2021 Mar;17(3):133-134. doi: 10.1038/s41584-021-00575-5.

DOI:10.1038/s41584-021-00575-5
PMID:33452499
Abstract
摘要

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Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis.越来越多的证据表明 JAK 抑制剂在类风湿关节炎患者中的安全性。
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2023 Management Recommendations of Bangladesh Rheumatology Society on Pharmacological Treatment of Rheumatoid Arthritis With Synthetic and Biologic Disease-Modifying Drugs.

本文引用的文献

1
Venous Thromboembolism Risk With JAK Inhibitors: A Meta-Analysis.JAK 抑制剂相关的静脉血栓栓塞风险:一项荟萃分析。
Arthritis Rheumatol. 2021 May;73(5):779-788. doi: 10.1002/art.41580. Epub 2021 Mar 25.
2
Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.在类风湿关节炎中使用 upadacitinib 的安全性概况:SELECT 三期临床项目的综合分析。
Ann Rheum Dis. 2021 Mar;80(3):304-311. doi: 10.1136/annrheumdis-2020-218510. Epub 2020 Oct 28.
2023年孟加拉国风湿病学会关于使用合成和生物改善病情药物治疗类风湿关节炎的管理建议。
Cureus. 2024 Apr 30;16(4):e59395. doi: 10.7759/cureus.59395. eCollection 2024 Apr.
4
Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease.结肠炎相关结肠癌和炎症性肠病中的激酶信号传导。
Biomolecules. 2023 Nov 6;13(11):1620. doi: 10.3390/biom13111620.
5
Efficacy and safety of different Janus kinase inhibitors combined with methotrexate for the treatment of rheumatoid arthritis: a single-center randomized trial.不同 Janus 激酶抑制剂联合甲氨蝶呤治疗类风湿关节炎的疗效和安全性:一项单中心随机试验。
Adv Rheumatol. 2023 Oct 16;63(1):50. doi: 10.1186/s42358-023-00331-1.
6
Cardiovascular Risk Management in Patients Treated With Janus Kinase Inhibitors.接受 Janus 激酶抑制剂治疗的患者的心血管风险管理。
J Cardiovasc Pharmacol. 2024 May 1;83(5):392-402. doi: 10.1097/FJC.0000000000001470.
7
Managing Cardiovascular and Cancer Risk Associated with JAK Inhibitors.管理与 JAK 抑制剂相关的心血管和癌症风险。
Drug Saf. 2023 Nov;46(11):1049-1071. doi: 10.1007/s40264-023-01333-0. Epub 2023 Jul 25.
8
JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.JAK1 假激酶 V666G 突变体显性抑制 JAK3 磷酸化和 IL-2 信号通路。
Int J Mol Sci. 2023 Apr 6;24(7):6805. doi: 10.3390/ijms24076805.
9
Characteristics of Patients Treated with JAK Inhibitors in Rheumatoid Arthritis before versus after VTE Risk Warnings.类风湿关节炎患者在VTE风险警告前后接受JAK抑制剂治疗的特征。
J Clin Med. 2022 Dec 27;12(1):207. doi: 10.3390/jcm12010207.
10
Cardiovascular and Venous Thromboembolic Risk With Janus Kinase Inhibitors in Immune-Mediated Inflammatory Diseases: A Systematic Review and Meta-Analysis of Randomized Trials.免疫介导性炎症疾病中使用 Janus 激酶抑制剂的心血管和静脉血栓栓塞风险:一项随机试验的系统评价和荟萃分析
ACR Open Rheumatol. 2022 Oct;4(10):912-922. doi: 10.1002/acr2.11479. Epub 2022 Jul 28.