用电子顺磁共振波谱法研究稳定的 NO 形式在大鼠皮肤中的转位。
Study of Translocation of Stabilized NO Forms through Rat Skin using Electron Paramagnetic Resonance Method.
机构信息
National Medical Research Centre for Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
A. N. Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology", Russian Academy of Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2021 Jan;170(3):303-307. doi: 10.1007/s10517-021-05056-z. Epub 2021 Jan 16.
We studied the effect of dinitrosyl-iron complexes with N-acetyl-L-cysteine as a thiol-containing ligand (DNIC-Acc) after transdermal administration to rats. Electron paramagnetic resonance spectroscopy with a lipophilic NO spin trap (a complex of iron and diethyldithiocarbamate ions) showed that DNIC-Acc administration significantly increased the total level of NO in the lung and liver tissues of the animal, which was accompanied by a slight decrease in the mean BP (<10%).
我们研究了经皮给予含有巯基配体 N-乙酰-L-半胱氨酸的二硝酰基铁复合物（DNIC-Acc）对大鼠的影响。使用亲脂性 NO 自旋捕集物（铁和二乙基二硫代氨基甲酸盐离子的复合物）的电子顺磁共振波谱学显示，DNIC-Acc 给药可显著增加动物肺和肝组织中总一氧化氮（NO）水平，同时平均血压（BP）略有下降（<10%）。
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