3D 打印聚乳酸和聚乙交酯组织膜的生物相容性和生物可吸收性。

Biocompatibility and Bioresorption of 3D-Printed Polylactide and Polyglycolide Tissue Membranes.

机构信息

Peoples' Friendship University of Russia (RUDN), Moscow, Russia.

N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Science, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2021 Jan;170(3):356-359. doi: 10.1007/s10517-021-05066-x. Epub 2021 Jan 16.

DOI:10.1007/s10517-021-05066-x

PMID:33452990

Abstract

We studied biocompatibility and bioresorption of 3D-printed polylactide and polyglycolide tissue membranes. Ultrasound microscopy and histological examination showed that membranes fabricated of a copolymer of lactic and glycolic acids in a mass ratio of 1:9 are bioresorbed and have good biocompatibility with soft tissues (connective tissue, adipose tissue, and epithelium). An important feature of the copolymer membranes, which differs them from pure polylactide membranes, is the formation of a thin fibrous capsule that did not interfere its destruction by the mechanism of hydrolytic resorption.

摘要

我们研究了 3D 打印的聚乳酸和聚乙交酯组织膜的生物相容性和生物可吸收性。超声显微镜和组织学检查表明，由质量比为 1:9 的乳酸和乙交酯共聚物制成的膜可生物吸收，并且与软组织（结缔组织、脂肪组织和上皮组织）具有良好的生物相容性。共聚物膜的一个重要特征是形成了一层薄的纤维囊，这与纯聚乳酸膜不同，因为纤维囊不会干扰其通过水解吸收机制的破坏。