The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.
Mov Disord. 2021 Jun;36(6):1435-1440. doi: 10.1002/mds.28497. Epub 2021 Jan 16.
Impulsive-compulsive behaviors are common in Parkinson's disease (PD) patients. However, the basal ganglia dysfunctions associated with high impulsivity have not been fully characterized. The objective of this study was to identify the features associated with impulsive-compulsive behaviors in single neurons of the subthalamic nucleus (STN).
We compared temporal and spectral features of 412 subthalamic neurons from 12 PD patients with impulsive-compulsive behaviors and 330 neurons from 12 PD patients without. Single-unit activities were extracted from exploratory microrecordings performed during deep brain stimulation (DBS) implant surgery in an OFF medication state.
Patients with impulsive-compulsive behaviors displayed decreased firing frequency during bursts and a larger fraction of tonic neurons combined with weaker beta coherence. Information carried by these features led to the identification of patients with impulsive-compulsive behaviors with an accuracy greater than 80%.
Impulsive-compulsive behaviors in PD patients are associated with decreased bursts in STN neurons in the OFF medication state. © 2021 International Parkinson and Movement Disorder Society.
冲动-强迫行为在帕金森病（PD）患者中很常见。然而，与高冲动性相关的基底节功能障碍尚未得到充分描述。本研究的目的是确定与丘脑底核（STN）中冲动-强迫行为相关的特征。
我们比较了 12 名有冲动-强迫行为的 PD 患者和 12 名无冲动-强迫行为的 PD 患者的 412 个 STN 神经元的时频特征。在深部脑刺激（DBS）植入手术中，在药物停用状态下进行探索性微记录，提取单个单元活动。
有冲动-强迫行为的患者在爆发期间的放电频率降低，紧张性神经元的比例更大，β 相干性较弱。这些特征所携带的信息使我们能够以超过 80%的准确率识别出有冲动-强迫行为的患者。
PD 患者的冲动-强迫行为与药物停用状态下 STN 神经元爆发减少有关。© 2021 国际帕金森病和运动障碍学会。
