Taddeini Fabio, Ordali Erica, Govoni Alessandra, Piattellini Francesca, Valente Simone, Caremani Luca, Vergani Alberto A, Kaymak Ahmet, Rustichini Aldo, Russo Eleonora, Rapallini Chiara, Ramat Silvia, Mazzoni Alberto
The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy.
Department of Excellence for Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy.
Ann Clin Transl Neurol. 2025 Mar;12(3):631-636. doi: 10.1002/acn3.52249. Epub 2024 Nov 18.
Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB-), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB- nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.
冲动强迫行为（ICB）是帕金森病（PD）常见的非运动症状，常与多巴胺能药物（DD）治疗相关。我们研究了DD对伴有ICB（ICB+）和不伴有ICB（ICB-）的PD患者以及健康对照（HC）决策的急性影响。参与者进行了两次基于风险的决策任务，PD患者在摄入DD之前（DD OFF）和之后（DD ON）进行测试。在DD OFF状态下，所有组都形成了规避风险的策略。在DD ON状态下，ICB+患者（但ICB-患者和HC患者未出现这种情况）恢复为更具风险的选择。我们得出结论，DD对ICB+患者的决策有特定的强烈急性影响。
