The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa, 56025, Italy.
Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, 56025, Italy.
Ann Clin Transl Neurol. 2022 Apr;9(4):552-557. doi: 10.1002/acn3.51530. Epub 2022 Mar 2.
Impulsive-compulsive behaviors (ICB) are over-represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients (12 ICB+ and 12 ICB-) in an OFF medication state. We computed the firing regularity in the dorsal and ventral STN regions, and we compared their performance in discriminating ICB patients. Regularity of ventral neurons in ICB+ patients is higher and supports a significant discrimination between the two cohorts. These results substantiate a ventral location of neurons involved in impulsivity.
冲动-强迫行为（ICB）在帕金森病（PD）患者中过度表现。腹侧丘脑底核（STN）中的神经元可能在冲动调节中起主要作用。我们在停药状态下对 24 名 PD 患者（12 名 ICB+和 12 名 ICB-）的 742 个丘脑底核神经元的放电规律进行了特征描述。我们计算了背侧和腹侧 STN 区域的放电规律，并比较了它们在区分 ICB 患者方面的性能。ICB+患者腹侧神经元的规律性更高，支持两个队列之间的显著区分。这些结果证实了参与冲动的神经元位于腹侧。
