Department of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
Material Science IN MainZ (MAINZ), Graduate School of Excellence, Staudingerweg 9, 55128, Mainz, Germany.
Chemistry. 2021 Jun 4;27(32):8252-8263. doi: 10.1002/chem.202005197. Epub 2021 Mar 3.
The symmetric biphenol 3,3',5,5'-tetramethyl-2,2'-biphenol is a well-known ligand building block and is used in transition-metal catalysis. In the literature, there are several synthetic routes for the preparation of this exceptional molecule. Herein, the focus is on the sustainable electrochemical synthesis of 3,3',5,5'-tetramethyl-2,2'-biphenol. A brief overview of the developmental history of this inconspicuous molecule, which is of great interest for technical applications, but has many challenges for its synthesis, is provided. The electro-organic method is a powerful, sustainable, and efficient alternative to conventional synthesis to obtain this symmetric biphenol up to the kilogram scale. Another section of this article is devoted to different process management strategies in batch-type and flow electrolysis and their respective advantages.
对称双酚 3,3',5,5'-四甲基-2,2'-联苯是一种众所周知的配体砌块，用于过渡金属催化。在文献中，有几种合成这种特殊分子的方法。本文重点介绍了 3,3',5,5'-四甲基-2,2'-联苯的可持续电化学合成。简要概述了这个不起眼的分子的发展历史，它在技术应用中非常重要，但在合成方面却面临许多挑战。电有机方法是一种强大、可持续、高效的替代传统合成方法，可以在公斤级规模上获得这种对称联苯。本文的另一部分专门介绍了分批式和流动电解中的不同过程管理策略及其各自的优点。
