对意大利市场产品中 Δ-THC 和相关大麻素的调查：通过 LC-MS/MS 对食品、饮料和饲料进行的研究。

A survey of Δ-THC and relevant cannabinoids in products from the Italian market: A study by LC-MS/MS of food, beverages and feed.

机构信息

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Department of Chemistry, via Salute 2, Portici, NA 80055, Italy.

出版信息

Food Chem. 2021 Jun 1;346:128898. doi: 10.1016/j.foodchem.2020.128898. Epub 2020 Dec 25.

DOI:10.1016/j.foodchem.2020.128898

Abstract

In 2016, the European Commission recommended the Member States to monitor the content of Δ-tetrahydrocannabinol and other cannabinoids in food and feed derived from hemp and in food of animal origin for possible transfer from feed. Thus, the Italian Ministry of Health implemented a monitoring plan. To this aim, nine cannabinoids in beverages and food for human consumption and in feed were determined. The method applied, based on rapid clean-up and LC-MS/MS determination, was previously developed and in-house validated, evaluating the analytical performance in the concentration ranges 2-50 µg/L for beverages, 0.020-0.500 mg/kg for food and 0.100-10.0 mg/kg for feed. Then, it was applied to determine the cannabinoids in 78 food, 16 beverage and 6 feed samples, collected from the Italian market since 2017. The results are herein reported, for evaluation of both product characteristics and compliance to national maximum limits. Some study cases are also described.

摘要

2016 年，欧盟委员会建议成员国监测源自大麻的食品和饲料以及动物源食品中 Δ-四氢大麻酚和其他大麻素的含量，以防止其从饲料中转移。为此，意大利卫生部制定了监测计划。为此，对人类消费的饮料和食品以及饲料中的 9 种大麻素进行了测定。所应用的方法基于快速净化和 LC-MS/MS 测定，该方法是先前开发并内部验证的，评估了饮料中浓度范围为 2-50μg/L、食品中为 0.020-0.500mg/kg 和饲料中为 0.100-10.0mg/kg 的分析性能。然后，将其应用于测定自 2017 年以来从意大利市场采集的 78 种食品、16 种饮料和 6 种饲料样品中的大麻素。在此报告结果，以评估产品特性和遵守国家最大限量的情况。还描述了一些案例研究。