Department of Forensic Science, Soochow University, 215021 Suzhou, China.
Department of Forensic Science, Soochow University, 215021 Suzhou, China.
Clin Neurophysiol. 2021 Feb;132(2):554-567. doi: 10.1016/j.clinph.2020.11.034. Epub 2020 Dec 25.
To explore the multiple specific biomarkers and cognitive compensatory mechanisms of mild traumatic brain injury (mTBI) patients at recovery stage.
The experiment was performed in two sections. In Section I, using event-related potential, event-related oscillation and spatial phase-synchronization, we explored neural dynamics in 24 volunteered healthy controls (HC) and 38 patients at least 6 months post-mTBI (19 with epidural hematoma, EDH; 19 with subdural hematoma, SDH) during a Go/NoGo task. In Section II, according to the neuropsychological scales, patients were divided into sub-groups to assess these electroencephalography (EEG) indicators in identifying different rehabilitation outcomes of mTBI.
In Section I, mean amplitudes of NoGo-P3 and P3d were decreased in mTBI patients relative to HC, and NoGo-theta power in the non-injured hemisphere was decreased in SDH patients only. In Section II, patients with chronic neuropsychological defects exhibited more serious impairments of intra-hemispheric connectivity, whereas inter-hemispheric centro-parietal and frontal connectivity were enhanced in response to lesions.
EEG distinguished mTBI patients from healthy controls, and estimated different rehabilitation outcomes of mTBI. The centro-parietal and frontal connectivity are the main compensatory mechanism for the recovery of mTBI patients.
EEG measurements and network connectivity can track recovery process and mechanism of mTBI.
探索恢复期轻度创伤性脑损伤（mTBI）患者的多个特异性生物标志物和认知代偿机制。
实验分为两部分。在第一部分中，我们使用事件相关电位、事件相关振荡和空间相位同步，在 Go/NoGo 任务中，研究了 24 名自愿健康对照者（HC）和 38 名至少 6 个月 mTBI 后患者（19 名硬膜下血肿，SDH；19 名硬膜外血肿，EDH）的神经动力学。在第二部分中，根据神经心理学量表，将患者分为亚组，以评估这些脑电图（EEG）指标在识别不同 mTBI 康复结果方面的作用。
在第一部分中，与 HC 相比，mTBI 患者的 NoGo-P3 和 P3d 平均振幅降低，而 SDH 患者仅在非损伤半球的 NoGo-theta 功率降低。在第二部分中，慢性神经心理学缺陷的患者表现出更严重的半球内连接损伤，而损伤后的对侧顶枕和额部连接增强。
EEG 可将 mTBI 患者与健康对照者区分开来，并估计 mTBI 的不同康复结果。顶枕和额部连接是 mTBI 患者康复的主要代偿机制。
EEG 测量和网络连接可以跟踪 mTBI 的恢复过程和机制。
