轻创伤性脑损伤患者在提示连续执行任务过程中的行为和神经生理异常。
Behavioral and neurophysiological abnormalities during cued continuous performance tasks in patients with mild traumatic brain injury.
机构信息
Department of Neurosurgery The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China.
Department of Neuroscience The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China.
出版信息
Brain Behav. 2018 Apr 15;8(5):e00966. doi: 10.1002/brb3.966. eCollection 2018 May.
OBJECTIVE
This study's aim was to investigate the features and neural mechanisms of sustained attention in patients with mild traumatic brain injury (mTBI) by comparing and analyzing neuropsychological, behavioral, event-related potentials, and event-related desynchronization and synchronization between mTBI patients and healthy controls.
METHODS
Twenty mTBI patients with mTBI and 20 healthy controls underwent the Mini-Mental State Examination (MMSE) and a cued continuous performance task (AX-CPT). Neuropsychological, behavioral, and electroencephalogram (EEG) data were collected and analyzed.
RESULTS
There were significant differences between the mTBI group and the control group in their MMSE total scores, attention, and calculation, but there were no significant differences in orientation, memory, recall, and verbal scores. There were significant differences between the mTBI group and the control group in hitting the number, reaction time, and the number of errors of omission, but there were no significant differences in the number of false errors. The amplitude of Go-N2 and Nogo-N2 was significantly smaller for the mTBI group than that for the control group. The amplitude of Go-P3 was significantly smaller for the mTBI group than that for the control group, but not for the amplitude of Nogo-P3. The Go-αERS were significantly less for the mTBI group than for the control group during the 0-200 ms after the stimulus onset. The Go-αERD and Nogo-αERD were significantly less for the mTBI group than for the control group during the 600-1,000 ms after the stimulus onset. The Go-βERS were significantly less for the mTBI group than for the control group during the 200-400 ms after the stimulus onset. There were no significant differences in the Nogo-αERS and Nogo-βERD/ERS between the mTBI group and the control group.
CONCLUSION
Patients with mTBI exhibited impairments in sustained attention and conflict monitoring, while response inhibition may have been spared.
目的
通过对比分析轻度创伤性脑损伤（mTBI）患者与健康对照者的神经心理学、行为学、事件相关电位（ERP）及事件相关去同步/同步（ERD/ERS），探讨 mTBI 患者持续性注意的特点及神经机制。
方法
20 例 mTBI 患者和 20 名健康对照者接受了简易精神状态检查（MMSE）和线索连续执行任务（AX-CPT）。采集并分析神经心理学、行为学和脑电图（EEG）数据。
结果
mTBI 组 MMSE 总分、注意力、计算力评分均显著低于对照组，而定向力、记忆力、回忆力、言语评分差异无统计学意义；mTBI 组 Hits 数、反应时、遗漏错误数显著多于对照组，而虚报错误数差异无统计学意义；mTBI 组 Go-N2、Nogo-N2 波幅显著小于对照组，Go-P3 波幅显著小于对照组，而 Nogo-P3 波幅差异无统计学意义；mTBI 组刺激后 0-200 ms Go-αERS 显著小于对照组，刺激后 600-1000 ms Go-αERD、Nogo-αERD 显著小于对照组；mTBI 组刺激后 200-400 ms Go-βERS 显著小于对照组，而 Nogo-αERS、Nogo-βERD/ERS 与对照组差异无统计学意义。
结论
mTBI 患者持续性注意和冲突监测受损，而反应抑制可能未受影响。
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