Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran.
DNA Repair (Amst). 2021 Feb;98:103047. doi: 10.1016/j.dnarep.2021.103047. Epub 2021 Jan 9.
Our genome bears tens of thousands of harms and devastations per day; In this regard, numerous sophisticated and complicated mechanisms are embedded by our cells in furtherance of remitting an unchanged and stable genome to their next generation. These mechanisms, that are collectively called DDR, have the duty of detecting the lesions and repairing them. it's necessary for the viability of any living cell that sustain the integrity and stability of its genetic content and this highlights the role of mediators that transduce the signals of DNA damage to the cell cycle in order to prevent the replication of a defective DNA. In this paper, we review the signaling pathways that lie between these processes and define how different ingredients of DDR are also able to affect the checkpoint signaling.
我们的基因组每天都会承受数万个损伤和破坏；在这方面，我们的细胞中嵌入了许多复杂的机制，以将不变和稳定的基因组传递给下一代。这些机制统称为 DDR，负责检测损伤并进行修复。任何活细胞的生存都需要维持其遗传物质的完整性和稳定性，这凸显了信号转导介质的作用，这些介质将 DNA 损伤信号传递到细胞周期，以防止有缺陷的 DNA 复制。在本文中，我们回顾了这些过程之间的信号通路，并定义了 DDR 的不同成分如何能够影响检查点信号。
