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Murici（Byrsonima crassifolia（L.）Kunth 和 verbascifolia（L.）DC）和 Taperebá（Spondias mombin L.）提取物对人前列腺癌细胞系（PC-3）的抗增殖和促凋亡作用。

Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Taperebá (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3).

机构信息

Laboratory of Functional Foods, University of State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

Fluminense Federal University, Food and Nutrition Department of Nutrition and Dietetics, Integrated Food and Nutrition Center (CIAN), Rio de Janeiro, Brazil.

出版信息

Asian Pac J Cancer Prev. 2024 Apr 1;25(4):1339-1347. doi: 10.31557/APJCP.2024.25.4.1339.

DOI:10.31557/APJCP.2024.25.4.1339
PMID:38679995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11162719/
Abstract

OBJECTIVE

The present study aimed to evaluate the antiproliferative and apoptotic effects of extracts obtained from the murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and taperebá (Spondias mombin L.) pulps, on cell proliferation, cell cycle and apoptosis on human prostate cell line (PC-3).

METHODS

Four extract was produced from the pulps:  murici aqueous extract (MA), taperebá aqueous extract (TA), murici ethanolic extract (ME) and taperebá ethanolic extract (TE). In the present study, the analysis of cell viability, cell cycle and apoptosis analyze were performed using the MTT method and flow cytometry.

RESULTS

The results showed that murici and taperebá extracts proved to be inhibitors of cell growth, modulation of cell cycle promoters and capable of enhancing the death in prostate carcinoma cells PC-3; suggesting a regulatory effect in prostate cell line, depending on type of extract and dosage used.

CONCLUSION

These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer.

摘要

目的

本研究旨在评估从 murici（Byrsonima crassifolia（L.）Kunth 和 verbascifolia（L.）DC）和 taperebá（Spondias mombin L.）果肉中获得的提取物对人前列腺癌细胞系（PC-3）增殖、细胞周期和凋亡的抗增殖和促凋亡作用。

方法

从果肉中制备了四种提取物：murici 水提取物（MA）、taperebá 水提取物（TA）、murici 乙醇提取物（ME）和 taperebá 乙醇提取物（TE）。在本研究中，使用 MTT 法和流式细胞术分析细胞活力、细胞周期和凋亡分析。

结果

结果表明，murici 和 taperebá 提取物被证明是细胞生长的抑制剂，可调节细胞周期促进剂，并能增强前列腺癌细胞 PC-3 的死亡；提示提取物的类型和使用剂量对前列腺细胞系有调节作用。

结论

这些结果为这些生物活性提取物在预防和治疗前列腺癌中的应用开辟了一系列前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/5ea3d25ba458/APJCP-25-1339-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/7af35ea66672/APJCP-25-1339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/c3f9ac2a9fd4/APJCP-25-1339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/81645a993a3d/APJCP-25-1339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/5614c56097a8/APJCP-25-1339-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/8aad484e97e7/APJCP-25-1339-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/5ea3d25ba458/APJCP-25-1339-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/7af35ea66672/APJCP-25-1339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/c3f9ac2a9fd4/APJCP-25-1339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/81645a993a3d/APJCP-25-1339-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/5614c56097a8/APJCP-25-1339-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/8aad484e97e7/APJCP-25-1339-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37d7/11162719/5ea3d25ba458/APJCP-25-1339-g006.jpg

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