马拉色菌属种在银屑病患者皮肤的分布。

Distribution of Malassezia species on the skin of patients with psoriasis.

机构信息

Department of Mycology, Shanghai Dermatology Hospital, 1278 Baode Road, Shanghai, China.

出版信息

J Mycol Med. 2021 Jun;31(2):101111. doi: 10.1016/j.mycmed.2021.101111. Epub 2021 Jan 7.

DOI:10.1016/j.mycmed.2021.101111

PMID:33454614

Abstract

INTRODUCTION

Malassezia species can induce the expression of interleukin-17 (IL-17), which plays an important role in the inflammatory and immune response in psoriasis (PS). The purpose of this study was to investigate the Malassezia species composition in patients with PS and healthy individuals and explore the role of Malassezia species in the pathogenesis of PS.

MATERIALS AND METHODS

A total of 28 patients with PS and 10 age- and sex-matched healthy individuals participated in this study. Specimens collected from the lesional and non-lesional skin of patients with PS and the skin of healthy individuals were analyzed by using nested PCR.

RESULTS

The relative abundance of Malassezia species was 84.96% in healthy subjects, more than twice that in patients with PS (P<0.01). M. restricta (43.09%) and M. globosa (41.38%) were the main Malassezia species in patients with PS followed by M. furfur (4.84%) and M. sympodialis (2.49%). M. sympodialis accounted for 18. 81% of the Malassezia species in healthy subjects, which was nearly eight times higher than in patients with PS (P<0.01). Further, M. furfur was detected both on lesional and non-lesional psoriatic skin, but it was not found on the skin of healthy individuals.

CONCLUSIONS

The Malassezia species composition in patients with PS differed from that of healthy individuals. M. restricta and M. globosa were the main Malassezia species in patients with PS.

摘要

简介

马拉色菌属可诱导白细胞介素-17（IL-17）的表达，而白细胞介素-17 在银屑病（PS）的炎症和免疫反应中发挥着重要作用。本研究旨在调查 PS 患者和健康个体中的马拉色菌属种类组成，并探讨马拉色菌属在 PS 发病机制中的作用。

材料与方法

本研究共纳入 28 例 PS 患者和 10 例年龄和性别匹配的健康个体。通过巢式 PCR 分析 PS 患者皮损和非皮损皮肤以及健康个体皮肤的标本。

结果

健康个体中马拉色菌属的相对丰度为 84.96%，明显高于 PS 患者（P<0.01）。PS 患者中主要的马拉色菌属为 M. restricta（43.09%）和 M. globosa（41.38%），其次为 M. furfur（4.84%）和 M. sympodialis（2.49%）。M. sympodialis 在健康个体中的马拉色菌属占比为 18.81%，几乎是 PS 患者的 8 倍（P<0.01）。此外，M. furfur 存在于 PS 患者的皮损和非皮损皮肤中，但不存在于健康个体的皮肤中。